NDLI: Nonlinear resonance behaviour and shell property estimates from individual microbubbles in the 4-13 MHz range assessed with low amplitude acoustic spectroscopy

Content Provider	IEEE Xplore Digital Library
Author	Helfield, B. Goertz, D.E.
Copyright Year	2012
Description	Author affiliation: Sunnybrook Res. Inst., Toronto, ON, Canada (Helfield, B.; Goertz, D.E.)
Abstract	There is an increasing interest in contrast applications in the 5-15 MHz range. In order to improve image quality and agent design, a greater understanding of microbubble behaviour in this frequency range is required. In this study, individual lipid encapsulated microbubbles (Definity and Target-Ready MicroMarker) were insonified at low pressures (<; 25 kPa) using an “acoustic spectroscopy” approach; namely insonicated with a sequence of tone bursts from 4 to 13.5 MHz in order to investigate frequency dependent scattering. The fundamental radial excursion amplitude was calculated from the frequency dependent scattering in order to produce a resonance curve for a given bubble. Over the size range of 2.5 to 4 μm, 69% of Target-Ready MicroMarker exhibited an asymmetric resonance, characterized by a skewing of the resonance curve and indicative of nonlinear behaviour. For Definity, these responses were observed for 8% over the size range 1.7 to 3.1 μm. For the subset of bubbles exhibiting linear, symmetric resonance curves, shell elasticity and viscosity values were estimated. Target-Ready MicroMarker is characterized by a stiffer shell $(3<;χ_{0}<;5)$ N/m than Definity $(0.5<;χ_{0}<;2.5)$ N/m, and distinct strain-softening and shear-thinning rheological behaviour. For Definity, no clear strain or shear rate dependence of the shell properties is evident.
Starting Page	394
Ending Page	397
File Size	655210
Page Count	4
File Format	PDF
ISBN	9781467345613
ISSN	19485719
e-ISBN	9781467345620
DOI	10.1109/ULTSYM.2012.0097
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2012-10-07
Publisher Place	Germany
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Elasticity Resonant frequency Ultrasonic imaging Viscosity Acoustics Strain Transducers shear thinning microbubbles shell properties characterization ultrasound contrast agent strain softening
Content Type	Text
Resource Type	Article

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