NDLI: Counter-propagation interaction for contrast-enhanced ultrasound imaging

Content Provider	IEEE Xplore Digital Library
Author	Renaud, G. Bosch, J.G. de Jong, N. van der Steen, A.F.W. Shamdasani, V. Entrekin, R.
Copyright Year	2012
Description	Author affiliation: Philips Healthcare, Bothell, WA, USA (Shamdasani, V.; Entrekin, R.) \|\| Dept. Biomed. Eng., Thorax Center Erasmus Med. Center, Rotterdam, Netherlands (Renaud, G.; Bosch, J.G.; de Jong, N.; van der Steen, A.F.W.)
Abstract	Most techniques for contrast-enhanced ultrasound imaging such as phase inversion and amplitude modulation require linear propagation to detect nonlinear scattering of contrast agent microbubbles. Waveform distortion due to nonlinear propagation impairs the ability to distinguish contrast agent microbubbles from tissue. This leads to erroneous detection of contrast agent behind any vessel or blood pool containing contrast agent. These artifacts can significantly impair the accuracy of medical diagnoses. Unlike biological tissue, lipid-coated gas microbubbles used as contrast agent allow the interaction of two ultrasound waves propagating in opposite directions (counter-propagation). We describe a strategy to detect microbubbles based on counter-propagation interaction that is free from nonlinear propagation artifacts. The new method was implemented in an ultrasound scanner (Philips iU22 and L9-3 probe) and tested in vitro in a tissue-mimicking phantom containing a cavity filled with a 1:1000 dilution of BR14 contrast agent (Bracco). It is compared to the default contrast mode of the scanner employing amplitude modulation as a technique to detect contrast agent microbubbles. A low acoustic pressure (110 kPa peak pressure) as used in vivo for carotid imaging is employed in our in vitro study. Whereas amplitude modulation produces a pseudo-enhancement behind the cavity in the contrast image, the pulse sequence exploiting counterpropagating wave interaction is free from artifacts due nonlinear propagation in contrast agent.
Starting Page	1
Ending Page	4
File Size	736688
Page Count	4
File Format	PDF
ISBN	9781467345613
ISSN	19485719
e-ISBN	9781467345620
DOI	10.1109/ULTSYM.2012.0169
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2012-10-07
Publisher Place	Germany
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Ultrasonic imaging Imaging Amplitude modulation Acoustics In vitro Cavity resonators Cutoff frequency artifact Ultrasound imaging contrast agent counter-propagation subharmonic emission nonlinear propagation
Content Type	Text
Resource Type	Article

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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