NDLI: Photoacoustic measurements of single red blood cells

Content Provider	IEEE Xplore Digital Library
Author	Strohm, E.M. Hysi, E. Kolios, M.C.
Copyright Year	2012
Description	Author affiliation: Dept. of Phys., Ryerson Univ. Toronto, Toronto, ON, Canada (Strohm, E.M.; Hysi, E.; Kolios, M.C.)
Abstract	A photoacoustic method to infer the size, shape and orientation of single RBCs is presented. Diseased or damaged RBCs frequently have abnormal shapes and sizes, which can result from a variety of diseases. When using frequencies between 100 and 500 MHz, the photoacoustic power spectrum from RBCs has periodically varying minima and maxima that depend on the size and shape of the RBC. The signals from RBCs in a vertical and horizontal orientation relative to the transducer were compared to numerical simulations using a finite element model. Three different shapes commonly used to model RBCs were examined (at constant volume): a biconcave disk, an oblate ellipsoid and a sphere. For a single biconcave shaped RBC, good agreement in the shape of the power spectrum was observed between measured and numerical simulations for the RBC in both the vertical and horizontal orientation relative to the transducer. When the RBC was placed in a hypotonic solution, it swelled to a spherical shape. In this case, good agreement was observed between the measured signal and the spherical model. In this paper, we show that the photoacoustic power spectrum can be used to infer the size, shape and orientation of single RBCs.
Starting Page	1406
Ending Page	1409
File Size	515708
Page Count	4
File Format	PDF
ISBN	9781467345613
ISSN	19485719
e-ISBN	9781467345620
DOI	10.1109/ULTSYM.2012.0351
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2012-10-07
Publisher Place	Germany
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Shape Transducers Optical imaging Acoustics Finite element analysis Numerical models Numerical simulation
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
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9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

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