NDLI: DNA-conjugated gold nanoparticles for ultrasound targeted drug delivery

Content Provider	IEEE Xplore Digital Library
Author	Shih-Tsung Kang Yun-Ling Luo Yu-Fen Huang Chih-Kuang Yeh
Copyright Year	2012
Description	Author affiliation: Dept. of Biomed. Eng. & Environ. Sci., Nat. Tsing Hua Univ., Hsinchu, Taiwan (Shih-Tsung Kang; Yun-Ling Luo; Yu-Fen Huang; Chih-Kuang Yeh)
Abstract	A novel platform based on gold nanoparticles (Au NPs) coupled with double-stranded DNA sequences and aptamers (referred to as ds(sgc8c)-Au NPs) was developed for ultrasoundcontrolled targeted drug delivery. The sgc8c aptamers with high affinity to CCRF-CEM (T-cell leukemia) cells facilitated the cellular uptake of ds(sgc8c)-Au NPs. The aptamers were extended with repeated CG base pairs for loading anticancer drugs doxorubicin (Dox). After incubated with ds(sgc8c)-Au NPs for 2 h, the cells were irradiated by 10-MHz high-intensity focused ultrasound (HIFU) at a focal spatial-average temporal-average intensity of 140 $W/cm^{2}$ for 10 min. It was found that the inertial cavitation induced by HIFU drove the specific release of Dox molecules from ds(sgc8c)-Au NPs as indicated by the increase in Dox fluorescence. The temperature within the focal volume only increased by 3°C during the irradiation, but reducing the gas content in the cell medium resulted in a 50% decrease in the fluorescence enhancement. This system can serve as a novel ultrasoundresponsive therapeutic system, showing great promise in targeted drug delivery for remote control of high spatial/temporal resolution as well as reductions in undesirable side effects.
Starting Page	1866
Ending Page	1868
File Size	1589105
Page Count	3
File Format	PDF
ISBN	9781467345613
ISSN	19485719
e-ISBN	9781467345620
DOI	10.1109/ULTSYM.2012.0468
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2012-10-07
Publisher Place	Germany
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Gold Drugs Ultrasonic imaging Fluorescence Radiation effects DNA Targeted drug delivery high-intensity focused ultrasound gold nanoparticle aptamer controlled drug release targeted chemotherapy
Content Type	Text
Resource Type	Article

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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