NDLI: Magnetic trapping and photoacoustic detection of rare circulating tumor cells

Content Provider	IEEE Xplore Digital Library
Author	Chenwei Wei Jinjun Xia Pelivanov, I.M. Xiaoge Hu Xiaohu Gao O'Donnell, M.
Copyright Year	2012
Description	Author affiliation: Dept. of Bioeng., Univ. of Washington, Seattle, WA, USA (Chenwei Wei; Jinjun Xia; Pelivanov, I.M.; Xiaoge Hu; Xiaohu Gao; O'Donnell, M.)
Abstract	The presence of circulating tumor cells (CTCs) in the vasculature directly correlates with the likelihood of metastasis development. Their rarity, however, makes them difficult to detect. Recently, the potential of photoacoustic (PA) imaging for sensitive detection of nanoparticle-targeted diseased cells has been demonstrated. However, the strong blood background can easily mask the weak signal from targeted CTCs. The goal of this study is to utilize a multifunction nanoparticle composite molecularly targeted to CTCs, enabling magnetic trapping for rare cell accumulation with simultaneous PA imaging for detection. This technique greatly increases both the sensitivity and specificity of CTC detection. As an initial test, human prostate cancer cells, LNCaP, targeted with a nanocomposite combining a gold nanorod core with magnetic nanoparticles, circulated in a 1.6-mm tube at a maximum flow rate of 12 ml/min, mimicking CTCs in the human radial artery. Results show that cells can be magnetically trapped, accumulated, and detected at a concentration of only 7 cells/ml, within the typical range of CTCs in peripheral vessels for an active tumor. Future work will focus on improving the sensitivity to detect a single targeted CTC.
Starting Page	1
Ending Page	4
File Size	304512
Page Count	4
File Format	PDF
ISBN	9781467345613
ISSN	19485719
e-ISBN	9781467345620
DOI	10.1109/ULTSYM.2012.0302
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2012-10-07
Publisher Place	Germany
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Magnetic resonance imaging Charge carrier processes Electron tubes Magnetoacoustic effects Tumors Magnetic separation magneto-optical coupled nanoparticles circulating tumor cells molecular imaging magnetomotive photoacoustic imaging
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in