NDLI: Feasibility and safety of transthoracic cardiac acoustic radiation force impulse imaging methods

Content Provider	IEEE Xplore Digital Library
Author	Bradway, D.P. Hollender, P.J. Goswami, R. Wolf, P.D. Trahey, G.E.
Copyright Year	2012
Description	Author affiliation: Duke Univ., Durham, NC, USA (Bradway, D.P.; Hollender, P.J.; Goswami, R.; Wolf, P.D.; Trahey, G.E.)
Abstract	This work examines clinical feasibility of using noninvasive transthoracic echocardiography techniques to visualize temporal variations of stiffness through the cardiac cycle using acoustic radiation force impulse (ARFI) imaging. Custom M-mode ARFI sequences were implemented on a Verasonics Research Platform using a Philips/ATL P4-2 phased-array echocardiography transducer. The research systems robust power supply, full parallel-receive capability, and programmable interface enabled sustained excitations, rapid data acquisition, and real-time processing and display of images in the clinic. An extended radiation force pulse length of 480 μs was used to produce tissue displacements up to 12μm around a region of excitation focused at 3 cm. Quadratic motion filters were used to separate ARFI excitation-induced displacements from intrinsic cardiac and respiratory physiological motion artifacts. Acoustic intensity and face heating measurements, as well as finite element method tissue focal heating simulations, were completed. These measurements and simulations calibrated the sequences with respect to the FDA acoustic exposure limits for intensity, mechanical index (MI) and tissue heating. Tests were conducted in phantom and animal models in preparation for the clinical trial. A series of 7 healthy volunteers were scanned in accordance with an approved Duke University Medical Center Institutional Review Board (IRB) protocol. Measurements were acquired from the apical 4 chamber view of the apex, at power levels with MI's ranging from 1.9-3.0. During each M-mode ARFI acquisition, the matched ECG signal was acquired, enabling registration with cardiac cycle. The M-mode ARFI displacement images reflect the expected myocardial stiffness changes through the cardiac cycle, with greatest displacements in diastole and lowest in systole. In the 7 volunteers, the mean displacements throughout the cardiac cycle rose with increasing transmit power level. The ratio of diastolic-to-systolic displacement was examined as a possible indicator of myocardial health. In this study, the measured ratios were in range up to 3.1:1 for the 7 patients, showing agreement with previous ratios reported by an animal studies using transthoracic, intracardiac and epicardial imaging methods. These preliminary clinical results support the feasibility of real-time imaging of cardiac stiffness in vivo using transthoracic ARFI imaging.
Starting Page	2027
Ending Page	2030
File Size	376939
Page Count	4
File Format	PDF
ISBN	9781467345613
ISSN	19485719
e-ISBN	9781467345620
DOI	10.1109/ULTSYM.2012.0507
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2012-10-07
Publisher Place	Germany
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Imaging Acoustics Force Heating Myocardium Ultrasonic imaging Tracking
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

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