NDLI: Viscoelastic Strain Response (ViSR) ultrasound assessment of viscoelastic properties in human duchenne muscular dystrophy, in vivo

Content Provider	IEEE Xplore Digital Library
Author	Scola, M.R. Caughey, M.C. Meyer, D.O. Emmett, R. Howard, J.F. Chopra, M. Gallippi, C.M.
Copyright Year	2012
Description	Author affiliation: Joint Dept. of Biomed. Eng., Univ. of North Carolina at Chapel Hill, Chapel Hill, NC, USA (Scola, M.R.; Gallippi, C.M.) \|\| Dept. of Phys. & Occupational Therapy, Univ. of North Carolina at Chapel Hill, Chapel Hill, NC, USA (Meyer, D.O.; Emmett, R.) \|\| Dept. of Med., Univ. of North Carolina at Chapel Hill, Chapel Hill, NC, USA (Caughey, M.C.) \|\| Dept. of Neurology, Univ. of North Carolina at Chapel Hill, Chapel Hill, NC, USA (Howard, J.F.; Chopra, M.)
Abstract	Duchenne muscular dystrophy (DMD) is an X-linked recessive disorder that is caused by a mutation in the gene for dystrophin leading to a loss of the dystrophin protein from the muscle cell (myofiber) membrane. Viscoelastic Strain Response (ViSR) ultrasound is a new, quantitative acoustic radiation force (ARF) based elastographic imaging method to calculate τ, the viscoelastic relaxation time constant for constant stress. We have investigated the use of ViSR imaging in human DMD. Imaging was performed in vivo on the right rectus femoris (RF), sartorius (SART), and gastrocnemius (GAST) muscles of two boys with DMD. The boys were 5- and 9-years-old at the time of imaging. ViSR results in the 5-year-old showed an average of 27.0%, 6.6%, and 18.2% fat/necrosis composition in the RF, SART, and GAST, respectively. In the 9-year old subject, ViSR showed an average fat/necrosis composition of 66.7% in the RF, 9.1% in the SART, and 37.2% in the GAST. These results are consistent with both the known phenotypic response of the three muscles and with functional testing results and point to ViSR's potential relevance as a novel outcome measure for diagnostics and clinical trials in DMD.
Starting Page	1355
Ending Page	1358
File Size	593766
Page Count	4
File Format	PDF
ISBN	9781467345613
ISSN	19485719
e-ISBN	9781467345620
DOI	10.1109/ULTSYM.2012.0338
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2012-10-07
Publisher Place	Germany
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Muscles Radio frequency Imaging Testing Ultrasonic imaging Transducers Hip Human Viscoelastic Strain Response (ViSR) Viscoelastic properties Duchenne Muscular Dystrophy
Content Type	Text
Resource Type	Article

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