NDLI: Three Novel Nano Particles Cytotoxicity Activity Evaluation

Content Provider	IEEE Xplore Digital Library
Author	Chi-Yea Yang Yu-Jin Peng Yi-Zhen Liauo Ching-Yi Lee Shang-Yu Tai
Copyright Year	2007
Description	Author affiliation: Dept. of Biotechnol., Vanung Univ., Taoyuan (Chi-Yea Yang; Yu-Jin Peng; Yi-Zhen Liauo; Ching-Yi Lee; Shang-Yu Tai)
Abstract	The authors present three novel nanoparticles cytotoxicity activity against culture cell lines, including, Chinese hamster ovary cells (CHO), human liver carcinoma cells (HepG2), human oral carcinoma cells (OECM1) and human human foreskin fibroblasts cells (HS68). Different nanocomposites reveal different cytotoxicity activity, but most analyzed results present similar consequence. Normal cells (CHO, HSP68) with more sensitive cytotoxicity activity (LD=5~6 ppm.) and the carcinoma cells (HepG2, OECM1) show more tolerance cytotoxicity activity (LD=8~10 ppm.) to nanoparticles. All these results demonstrate that, these three nanoparticles were toxicity to culture cells and the lethal concentrations were never lower than 10 ppm, typically. It means that nanoparticles should not be used in food industry or relative health-food products. Interestingly, when combined with another gold nanoparticle to test cytotoxicity activity with these cell lines, we found that gold nanoparticle decrease the cytotoxicity activity of all the analyzed cell lines, but the lethal concentrations of silver combined with gold nanoparticle were never lower than 14 ppm. These results suggest that nanoparticles should not be applied onto food chemistry discretionary, including the popular packaged water market.
Starting Page	1206
Ending Page	1208
File Size	3327832
Page Count	3
File Format	PDF
ISBN	1424406102
DOI	10.1109/NEMS.2007.352236
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2007-01-16
Publisher Place	Thailand
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Nanoparticles Humans Gold Liver Fibroblasts Nanocomposites Food industry Testing Silver Chemistry Cytotoxicity Nanoparticle
Content Type	Text
Resource Type	Article

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