NDLI: Multilayer Electrodes DEP Chip for Single-cell Level Impedance Measurement

Content Provider	IEEE Xplore Digital Library
Author	Cheng-Hsin Chuang Ching-Hua Wei You-Ming Hsu Jian-Tang Lu
Copyright Year	2007
Description	Author affiliation: Dept. of Mech. Eng., Southern Taiwan Univ. of Technol., Tainan (Cheng-Hsin Chuang; Ching-Hua Wei; You-Ming Hsu; Jian-Tang Lu)
Abstract	The authors demonstrated the capability of cell trapping with combination of dielectrophoresis (DEP) and 3D microstructures array in the prior work (Chen-Hsin Chuang, 2006). In the present study, in order to measure the variation of electric properties for a single cell under biochemical reactions, a novel design of multilayer electrodes is utilized to achieve both DEP positioning and impedance measurement with single-cell resolution. In this chip, three electrodes are separated by flow chamber and SU-8 holes array, respectively. Firstly, bioparticles can be trapped in SU-8 holes array by applying AC power on top ITO electrode and middle Au electrode on SU-8 surface. According to experimental results, the trapped bioparticles will be constrained in stationary due to microstructures for a long period of time without applying DEP force. Sequentially, the impedance measurement for bioparticles or cells can be performed by LCR meter. As the results shown, the resulting impedance can be varied by the size of trapped bioparticle. Therefore, this study not only provides an efficient way for trapping cell but also an alternative way to identify the size of particles by impedance measurement.
Starting Page	821
Ending Page	825
File Size	5895710
Page Count	5
File Format	PDF
ISBN	1424406102
DOI	10.1109/NEMS.2007.352144
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2007-01-16
Publisher Place	Thailand
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Nonhomogeneous media Electrodes Impedance measurement Microstructure Dielectrophoresis Electric variables measurement Position measurement Semiconductor device measurement Indium tin oxide Gold impedance DEP dielectrophoresis single eel
Content Type	Text
Resource Type	Article

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