NDLI: Study of Noninvasive Sampling of Subcutaneous Glucose by Reverse Iontophoresis

Content Provider	IEEE Xplore Digital Library
Author	Jian Liu Chunxiu Liu Hongmin Liu Liying Jiang Qingde Yang Xinxia Cai
Copyright Year	2007
Description	Author affiliation: Inst. of Electron., Chinese Acad. of Sci. (Jian Liu; Chunxiu Liu; Hongmin Liu; Liying Jiang; Qingde Yang; Xinxia Cai)
Abstract	As the symmetry of the iontophoresis technique, the reverse iontophoresis technique of extracting and analyzing glucose from the subcutaneous space to the skin surface was described in this paper, as a preliminary step towards the development of noninvasive extracting and analyzing glucose concentrations of human body. Reverse iontophoretic experiments on glucose in sodium chloride solution were performed. The extracted current density was constant 0.5 $mA/cm^{2}$ and glucose concentration under naked mouse skin was changed in a range of 0 ~ 18 mM. A sensitive amperometric biosensor was designed and prepared for the measurement of the glucose extracted from the subcutaneous space. Our results indicate that reverse iontophoretic extraction has a good correlation with the subcutaneous glucose concentration (r=0.98, n=7). Further research also demonstrates that by addition of EDTA into the cathodal electrolyte could augment the glucose transportation across the naked mouse skin by reverse iontophoresis.
Starting Page	707
Ending Page	710
File Size	4739872
Page Count	4
File Format	PDF
ISBN	1424406102
DOI	10.1109/NEMS.2007.352116
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2007-01-16
Publisher Place	Thailand
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Sampling methods Sugar Skin Mice Blood Transducers Biosensors Space technology Animals Diabetes Noninvasive sampling Reverse iontophoresis Thin-film electrode Glucose Biosensor
Content Type	Text
Resource Type	Article

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