NDLI: Attenuation of Cellular Inflammation Using Glucocorticoid-Functionalized Copolymers

Content Provider	IEEE Xplore Digital Library
Author	Chow, E.K. Pierstorff, E. Genhong Cheng Yu-Chong Tai Dean Ho
Copyright Year	2007
Description	Author affiliation: Dept. of Microbiol., Immunology, & Molecular Genetics, California Univ., Los Angeles, CA (Chow, E.K.)
Abstract	This work has demonstrated the functionalization of an amphiphilic diblock copolymer, comprised of polyethylene oxide-polymethyl methacrylate (PEO-PMMA), as well as a triblock copolymer comprised of polymethyloxazoline-polydimethylsiloxane-polymethyloxazoline(PMOXA-PDMS-PM OXA) with the dexamethasone (Dex) glucocorticoid anti-inflammatory. Interfacial deposition of the copolymer and the Dex molecules and subsequent transfer of the hybrid materials to solid substrates were characterized to evaluate the potential of utilizing this composite material as a suppressor of cyto-inflammation to enhance implant biocompatibility. Given the extremely thin dimensions of the film (~4nm), this material would have negligible impact upon the size of the coated device to preclude biological stress. The composite films were interfaced with the RAW264.7 murine macrophages which served as a model cell line for the evaluation of nuclear factor-kappaB (NF-KB)-induced production of a host of inflammatory cytokines including interleukin-6, interleukin-12, tumor necrosis factor-alpha (TNFalpha), as well as the inducible nitric oxide synthase signaling factor which is known to be involved with stress-related processes such as neuronal damage. Lipopolysaccharide or LPS is a component of bacterial membranes that elicits cellular stress following application to RAW cell cultures. Following the induced stress response, significant reductions in the expression of genes associated with the aforementioned cytokines and signaling molecules indicated that macrophages in direct contact with the functionalized copolymer were able to collect Dex that was released from within the polymer network to attenuate cyto-inflammation mechanisms. This composite membrane represents a medically-relevant technology to promote chronic implant functionality and preclusion of bio-fouling.
Starting Page	1039
Ending Page	1043
File Size	6201692
Page Count	5
File Format	PDF
ISBN	1424406102
DOI	10.1109/NEMS.2007.352195
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2007-01-16
Publisher Place	Thailand
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Attenuation Stress Biological materials Composite materials Implants Biomembranes Polyethylene Solids Substrates Biological system modeling biomaterials Cell regulation copolymer
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

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