NDLI: Mechanobiological Signal Transduction in Differentiating Chondrocyte and New Configuration for Mechanical Stress Culture

Content Provider	IEEE Xplore Digital Library
Author	Takahashi, I. Masuda, T. Arai, F. Anada, T. Fukuda, T. Suzuki, O. Takano-Yamamoto, T.
Copyright Year	2007
Description	Author affiliation: Div. of Orthodontics & Dentofacial Orthopedics, Tohoku Univ., Sendai (Takahashi, I.; Masuda, T.)
Abstract	Musculoskeletal system regulates and supports mammalian body movement by generating force and by resisting to the force exerted on the body. Skeletal tissues, bone, cartilage, muscle and tendon are mechano-responsive tissues consisted of osteoblasts, chondrocytes, myocytes and fibroblasts and their specific extracellular matrices (ECMs). Mechanical stress presents a variety of effects on the metabolism and differentiation state of these cells. During bone growth, growth plate cartilage plays a pivotal role in growth in length of bone by providing templates consisted of cartilage specific ECM, which is replaced by bone. Chondrocytes, form cartilage in synovial joints and growth plates, respond to compressive force by activating their metabolism and progressing differentiation, while tensile stimulation inhibits their differentiation. Mechanical stimulation is translated into intracellular signaling, which regulates the differentiation state and metabolism of chondrocytes. To analyze the mechanobiological response, we have been developing mechanical stress culture device. Here, we present the mechanical stress culture device and mechnobiological response of differentiating chondrocytes to stretch stimulation.
Starting Page	1061
Ending Page	1064
File Size	4682356
Page Count	4
File Format	PDF
ISBN	1424406102
DOI	10.1109/NEMS.2007.352201
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2007-01-16
Publisher Place	Thailand
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Stress Bones Biochemistry Musculoskeletal system Muscles Tendons Fibroblasts Extracellular Brushless DC motors Electrochemical machining culture device chondrogenesis mechnial stress
Content Type	Text
Resource Type	Article

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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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Effects of mechanical stress and scaffold material on osteogenesis and chondrogenesis

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Mechanobiological Signal Transduction in Differentiating Chondrocyte and New Configuration for Mechanical Stress Culture

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