NDLI: Efficacy of cathodal transcranial direct current stimulation in drug-resistant epilepsy: A proof of principle

Content Provider	IEEE Xplore Digital Library
Author	Assenza, G. Campana, C. Formica, D. Schena, E. Taffoni, F. Di Pino, G. Di Lazzaro, V.
Copyright Year	2014
Description	Author affiliation: Center for Integrated Res. - Unit of Meas. & Biomed. Instrum., Univ. Campus Bio-Medico di Roma, Rome, Italy (Schena, E.) \|\| Lab. of Biomed. Robot. & Biomicrosystems, Univ. Campus Bio-Medico di Roma, Rome, Italy (Formica, D.; Taffoni, F.) \|\| Institure of Neurology, Univ. Campus Bio-Medico di Roma, Rome, Italy (Assenza, G.; Campana, C.; Di Pino, G.; Di Lazzaro, V.)
Abstract	It has been proved that Transcranial DCS (tDCS) can modulate cortical excitability, enhancing or decreasing, respectively by anodal or cathodal polarity. The short-term and lasting alterations induced by tDCS are strictly related to the charge density, duration of stimulation and the depth of neuron below the skull. Epilepsy represents a pathophysiological model of unbalanced relation between cortical excitation and inhibition. In this line, tDCS can be exploited to counterbalance the neuronal hyper-excitation through electric neural modulation. This paper aims at providing the efficacy of cathodal tDCS in reducing seizures' frequency in drug-resistant focal epilepsy. The study was single blind and sham-controlled with an observation period of one month during which the patients or the caregivers provided a detailed seizures' calendar (frequency as n°/week; basal, post sham and post tDCS). Patients received sham or real tDCS treatment on the 8th and 22th days. Two patients affected by focal resistant epilepsy were enrolled. They both underwent a consistent reduction of the seizures'frequency: about 70 % for Patient 1 and about 50% for Patient 2. This study represents the proof that cathodal tDCS may be efficient in reducing seizures'frequency in focal resistant epilepsy.
Sponsorship	IEEE Eng. Med. Biol. Soc.
Starting Page	530
Ending Page	533
File Size	633735
Page Count	4
File Format	PDF
ISBN	9781424479290
ISSN	1557170X
DOI	10.1109/EMBC.2014.6943645
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2014-08-26
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Epilepsy Electrodes Electroencephalography Neurons Drugs IEEE members
Content Type	Text
Resource Type	Article
Subject	Signal Processing Biomedical Engineering Health Informatics Computer Vision and Pattern Recognition

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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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