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Content Provider | IEEE Xplore Digital Library |
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Author | Rivolo, S. Nagel, E. Smith, N.P. Lee, J. |
Copyright Year | 2014 |
Description | Author affiliation: Fac. of Eng., Univ. of Auckland, Auckland, New Zealand (Smith, N.P.) || Div. of Imaging Sci. & Biomed. Eng, King's Coll. London, London, UK (Rivolo, S.; Nagel, E.; Lee, J.) |
Abstract | Coronary Wave Intensity Analysis (cWIA) is a technique capable of separating the effects of proximal arterial haemodynamics from cardiac mechanics. The cWIA ability to establish a mechanistic link between coronary haemodynamics measurements and the underlying pathophysiology has been widely demonstrated. Moreover, the prognostic value of a cWIA-derived metric has been recently proved. However, the clinical application of cWIA has been hindered due to the strong dependence on the practitioners, mainly ascribable to the cWIA-derived indices sensitivity to the pre-processing parameters. Specifically, as recently demonstrated, the cWIA-derived metrics are strongly sensitive to the Savitzky-Golay (S-G) filter, typically used to smooth the acquired traces. This is mainly due to the inability of the S-G filter to deal with the different timescale features present in the measured waveforms. Therefore, we propose to apply an adaptive S-G algorithm that automatically selects pointwise the optimal filter parameters. The newly proposed algorithm accuracy is assessed against a cWIA gold standard, provided by a newly developed in-silico cWIA modelling framework, when physiological noise is added to the simulated traces. The adaptive S-G algorithm, when used to automatically select the polynomial degree of the S-G filter, provides satisfactory results with ≤ 10% error for all the metrics through all the levels of noise tested. Therefore, the newly proposed method makes cWIA fully automatic and independent from the practitioners, opening the possibility to multi-centre trials. |
Sponsorship | IEEE Eng. Med. Biol. Soc. |
Starting Page | 5056 |
Ending Page | 5059 |
File Size | 749410 |
Page Count | 4 |
File Format | |
ISBN | 9781424479290 |
ISSN | 1557170X |
DOI | 10.1109/EMBC.2014.6944761 |
Language | English |
Publisher | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
Publisher Date | 2014-08-26 |
Publisher Place | USA |
Access Restriction | Subscribed |
Rights Holder | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
Subject Keyword | Noise Measurement Algorithm design and analysis Accuracy Standards Polynomials Myocardium |
Content Type | Text |
Resource Type | Article |
Subject | Signal Processing Biomedical Engineering Health Informatics Computer Vision and Pattern Recognition |
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