NDLI: Separation and capture of circulating tumor cells from whole blood using a bypass integrated microfluidic trap array

Content Provider	IEEE Xplore Digital Library
Author	Yousang Yoon Sunki Cho Seonil Kim Eunsuk Choi Rae-Kwon Kim Su-Jae Lee Onejae Sul Seung-Beck Lee
Copyright Year	2014
Description	Author affiliation: Inst. of Nano Sci. & Technol., Hanyang Univ., Seoul, South Korea (Onejae Sul) \|\| Dept. of Electron. Eng., Hanyang Univ., Seoul, South Korea (Yousang Yoon; Sunki Cho; Seonil Kim; Eunsuk Choi; Seung-Beck Lee) \|\| Dept. of Life Sci. & Res. Inst. for Natural Sci., Hanyang Univ., Seoul, South Korea (Rae-Kwon Kim; Su-Jae Lee)
Abstract	We report on a microfluidic trap array that separates and captures circulating tumor cells (CTCs) from whole blood. The device is a series array of microfluidic branches that utilizes the difference in flow rates between the bypass channel and the trap channel to allow CTCs in whole blood to be separated and trapped. Once a trap has captured a cell with diameter larger than the narrow trap outlet, additional cells arriving at the branch would flow towards the bypass channel due to its lower flow resistance. Results demonstrated that it was possible to capture CTCs from the whole blood of a mouse with full-blown metastasis. With further developments, the bypass integrated microfluidic trap array could become a useful tool for the early prognosis of cancer metastasis.
Sponsorship	IEEE Eng. Med. Biol. Soc.
Starting Page	4431
Ending Page	4434
File Size	929471
Page Count	4
File Format	PDF
ISBN	9781424479290
ISSN	1557170X
DOI	10.1109/EMBC.2014.6944607
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2014-08-26
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Microfluidics Blood Tumors Arrays Metastasis Mice
Content Type	Text
Resource Type	Article
Subject	Signal Processing Biomedical Engineering Health Informatics Computer Vision and Pattern Recognition

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Viable circulating tumor cell enrichment by flexible micro spring array

Microfluidic Liquid Filters for Leukocyte Isolation

Lab-on-a-chip for the isolation and characterization of circulating tumor cells

Deterministic Capture of Individual Circulating Tumor Cells Using a Flow-Restricted Microfluidic Trap Array

Using microfluidics to investigate tumor cell extravasation and T-cell immunotherapies

Microfluidic platforms for capturing circulating tumor cells

Red blood cells flows in rectilinear microfluidic chip

Detection of circulating melanoma cells in human blood using photoacoustic flowmetry

A new microfluidic device for electric lysis and separation of cells

Separation and capture of circulating tumor cells from whole blood using a bypass integrated microfluidic trap array

Similar Documents

Viable circulating tumor cell enrichment by flexible micro spring array

Microfluidic Liquid Filters for Leukocyte Isolation

Lab-on-a-chip for the isolation and characterization of circulating tumor cells

Deterministic Capture of Individual Circulating Tumor Cells Using a Flow-Restricted Microfluidic Trap Array

Using microfluidics to investigate tumor cell extravasation and T-cell immunotherapies

Microfluidic platforms for capturing circulating tumor cells

Red blood cells flows in rectilinear microfluidic chip

Detection of circulating melanoma cells in human blood using photoacoustic flowmetry

A new microfluidic device for electric lysis and separation of cells

Separation and capture of circulating tumor cells from whole blood using a bypass integrated microfluidic trap array