NDLI: Exact computation of probability landscape of stochastic networks of Single Input and Coupled Toggle Switch Modules

Content Provider	IEEE Xplore Digital Library
Author	Terebus, A. Youfang Cao Jie Liang
Copyright Year	2014
Description	Author affiliation: Fac. of Dept. of Bioeng., Univ. of Illinois at Chicago, Chicago, IL, USA (Jie Liang) \|\| Dept. of Bioeng., Univ. of Illinois at Chicago, Chicago, IL, USA (Terebus, A.; Youfang Cao)
Abstract	Gene regulatory networks depict the interactions between genes, proteins, and other components of the cell. These interactions often are stochastic that can influence behavior of the cells. Discrete Chemical Master Equation (dCME) provides a general framework for understanding the stochastic nature of these networks. However solving dCME is challenging due to the enormous state space, one effective approach is to study the behavior of individual modules of the stochastic network. Here we used the finite buffer dCME method and directly calculated the exact steady state probability landscape for the two stochastic networks of Single Input and Coupled Toggle Switch Modules. The first example is a switch network consisting of three genes, and the second example is a double switching network consisting of four coupled genes. Our results show complex switching behavior of these networks can be quantified.
Sponsorship	IEEE Eng. Med. Biol. Soc.
Starting Page	5228
Ending Page	5231
File Size	764940
Page Count	4
File Format	PDF
ISBN	9781424479290
ISSN	1557170X
DOI	10.1109/EMBC.2014.6944804
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2014-08-26
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Proteins Steady-state Switches Stochastic processes Mathematical model Chemicals Equations
Content Type	Text
Resource Type	Article
Subject	Signal Processing Biomedical Engineering Health Informatics Computer Vision and Pattern Recognition

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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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