NDLI: Implementation of the excitatory entorhinal-dentate-CA3 topography in a large-scale computational model of the rat hippocampus

Content Provider	IEEE Xplore Digital Library
Author	Gene Yu Dong Song Berger, T.W.
Copyright Year	2014
Description	Author affiliation: Dept. of Biomed. Eng., Center for Neural Eng., Program in Neurosci., Univ. of Southern California, Los Angeles, CA, USA (Berger, T.W.) \|\| Dept. of Biomed. Eng., Univ. of Southern California, Los Angeles, CA, USA (Gene Yu; Dong Song)
Abstract	The topography, or the anatomical connectivity, of the excitatory entorhinal-dentate-CA3 circuit of the rat hippocampus has been implemented for a large-scale, biologically realistic, computational model of the rat hippocampus. The implementation thus far covers only the excitatory synapses for the principal neurons in the hippocampal subregions. Starting from layer II of the entorhinal cortex, the projection of their perforant path axons has been mapped across the full extent of the dentate gyrus as well as to the CA3. The mossy fiber axon trajectories from the dentate granule cells to the CA3 pyramidal cells have been derived, incorporating the transverse route the fibers take through the CA3c and CA3b and the septo-temporal turn in the CA3a. The extensive arborization of the CA3 pyramidal axons have been modeled using 2-D, skewed Gaussian distributions which have been parametrized to exhibit the differences that exist among the CA3a, CA3b, and CA3c auto-associational projections. Using the limited samples available from the literature, key parameters for each projection have been interpolated as a function of transverse and/or septo-temporal position in order to create a more complete representation of the topography.
Sponsorship	IEEE Eng. Med. Biol. Soc.
Starting Page	6581
Ending Page	6584
File Size	1778012
Page Count	4
File Format	PDF
ISBN	9781424479290
ISSN	1557170X
DOI	10.1109/EMBC.2014.6945136
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2014-08-26
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Nerve fibers Hippocampus Surfaces Blades Organizations Computational modeling
Content Type	Text
Resource Type	Article
Subject	Signal Processing Biomedical Engineering Health Informatics Computer Vision and Pattern Recognition

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