NDLI: Fabrication and characterization of a high-resolution neural probe for stereoelectroencephalography and single neuron recording

Content Provider	IEEE Xplore Digital Library
Author	Pothof, F. Anees, S. Leupold, J. Bonini, L. Paul, O. Orban, G.A. Ruther, P.
Copyright Year	2014
Description	Author affiliation: Brain Center for Social & Motor Cognition, Ist. Italiano di Tecnol. (IIT), Parma, Italy (Bonini, L.) \|\| Dept. of Neurosciences, Univ. degli studi di Parma, Parma, Italy (Orban, G.A.) \|\| Dept. of Radiol., Univ. Med. Center Freiburg, Freiburg, Germany (Leupold, J.) \|\| Dept. of Microsyst. Eng. (IMTEK), Univ. of Freiburg, Freiburg, Germany (Pothof, F.; Anees, S.; Paul, O.; Ruther, P.)
Abstract	This paper reports on the design, fabrication, and characterization of neural probes for stereoelectroencephalography (SEEG). The probe specifically targets focal epilepsy as key application. However, probes of this type can also be used for the diagnosis and treatment of other neural dysfunctions such as Parkinson's disease or tremor, typically requiring deep brain probes. The probe fabrication, of which most processes are parallel batch processes, relies on a novel fabrication concept for rolling and gluing thin film polyimide sheets with integrated electrodes into permanent cylindrical shapes with diameters down to 800 μm. The SEEG probes, comprise several macro-electrodes designed to record local field potentials, and micro-electrodes positioned in-between, dedicated to monitoring single unit activity, with a total channel count of 32, despite the small diameter. While platinum micro-electrodes with a diameter of 35 μm have impedances of about 255 kΩ at 1 kHz, impedance values down to about 1.5 kΩ have been measured for the macro-electrodes. The devices have shown good compatibility with magnetic resonance imaging in a 9.4 T magnet, enabling the precise post-operative probe localization within the brain.
Sponsorship	IEEE Eng. Med. Biol. Soc.
Starting Page	5244
Ending Page	5247
File Size	3157364
Page Count	4
File Format	PDF
ISBN	9781424479290
ISSN	1557170X
DOI	10.1109/EMBC.2014.6944808
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2014-08-26
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Probes Electrodes Fasteners Silicon carbide Fabrication Polyimides Impedance
Content Type	Text
Resource Type	Article
Subject	Signal Processing Biomedical Engineering Health Informatics Computer Vision and Pattern Recognition

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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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