NDLI: Assessment of baroreflex sensitivity by continuous noninvasive monitoring of peripheral and central aortic pressure

Content Provider	IEEE Xplore Digital Library
Author	Kouchaki, Z. Butlin, M. Qasem, A. Avolio, A.P.
Copyright Year	2014
Description	Author affiliation: AtCor Med., Sydney, NSW, Australia (Qasem, A.) \|\| Australian Sch. of Adv. Med., Macquarie Univ., Sydney, NSW, Australia (Kouchaki, Z.; Butlin, M.; Avolio, A.P.)
Abstract	Noninvasive assessment of baroreceptor sensitivity (BRS) facilitates clinical investigation of autonomic function. The spontaneous sequence method estimates BRS using the continuous measurement of arterial pressure in the finger. Since the baroreceptors are centrally located (aortic arch, carotid arteries), this study assessed the use of a continuous aortic pressure signal derived from the peripheral pressure pulse to compute the BRS from changes in systolic pressure (SBP) and pulse interval (PI). BRS computed from central aortic (cBRS) and peripheral pressure (pBRS) was calculated in 12 healthy subjects (25-62 years, 7 females). The difference between pBRS and cBRS was calculated for four levels of pulse lags between changes in SBP and PI. For each lag and for the pooled data for all lags, cBRS was significantly correlated with pBRS $(r^{2}=0.82).$ The within subject difference ranged from -41.2% to 59.2%. This difference was not related to age, gender of hemodynamic parameters (systolic or diastolic pressure, heart rate, aortic pulse wave velocity). However 18.2% of the variance was due to the difference in the number of spontaneous pulse sequences used to determine values of cBRS and pBRS. The differences between pBRS and cBRS are in the range of values of BRS as those found, in other studies, to discriminate between patient groups with different levels of autonomic function. Findings of this study suggest that, given the heart rate dependent amplification of the arterial pressure pulse between the central aorta and the peripheral limbs, BRS determined from central aortic pressure derived from the peripheral pulse may provide an improved method for noninvasive assessment of baroreceptor function.
Sponsorship	IEEE Eng. Med. Biol. Soc.
Starting Page	2940
Ending Page	2943
File Size	708796
Page Count	4
File Format	PDF
ISBN	9781424479290
ISSN	1557170X
DOI	10.1109/EMBC.2014.6944239
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2014-08-26
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Blood pressure Baroreflex Heart rate Sensitivity Estimation Monitoring Pressure measurement
Content Type	Text
Resource Type	Article
Subject	Signal Processing Biomedical Engineering Health Informatics Computer Vision and Pattern Recognition

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