NDLI: Altered small-world anatomical networks in Apolipoprotein-E4 (ApoE4) carriers using MRI

Content Provider	IEEE Xplore Digital Library
Author	Goryawala, M. Qi Zhou Duara, R. Loewenstein, D. Cabrerizo, M. Barker, W. Adjouadi, M.
Copyright Year	2014
Description	Author affiliation: Dept. of Electr. Eng., Florida Int. Univ., Miami, FL, USA (Goryawala, M.; Qi Zhou; Cabrerizo, M.; Adjouadi, M.) \|\| Wien Center for Alzheimer's Disease & Memory Disorders, Mount Sinai Med. Center, Miami Beach, FL, USA (Duara, R.; Loewenstein, D.; Barker, W.)
Abstract	Apolipoprotein E (ApoE) gene and primarily its allele e4 have been identified as a risk factor for Alzheimer's disease (AD). The prevalence of the gene in 25-30% in the population makes it essential to estimate its role in neuroregulation and its impact on distributed brain networks. In this study, we provide computational neuroanatomy based interpretation of large-scale and small-world cortical networks in cognitive normal (CN) subjects with differing Apolipoprotein-E4 (ApoE4) gene expression. We estimated large-scale anatomical networks from cortical thickness measurements derived from magnetic resonance imaging in 147 CN subjects explored in relation to ApoE4 genotype (e4+ carriers (n=41) versus e4- non-carriers (n=106)). Brain networks were constructed by thresholding cortical thickness correlation matrices of 68 bilateral regions of the brain analyzed using well-established graph theoretical approaches. Compared to ApoE4 non-carriers, carriers showed increased interregional correlation coefficients in regions like precentral, superior frontal and inferior temporal regions. Interestingly most of the altered connections were intra-hemispheric limited primarily to the right hemisphere. Furthermore, ApoE4 carriers demonstrated abnormal small-world architecture in the cortical networks with increased clustering coefficient and path lengths as compared to non-carrier, suggesting a less optimal topological organization. Additionally non-carriers demonstrated higher betweenness in regions such as middle temporal, para-hippocampal gyrus, posterior cingulate and insula of the default mode network (DMN), also seen in subjects with AD and mild cognitive impairment (MCI). The results suggest that the complex morphological cortical connectivity patterns are altered in ApoE4 carriers as compared to non-carriers, providing evidence for disruption of integrity in large-scale anatomical brain networks.
Sponsorship	IEEE Eng. Med. Biol. Soc.
Starting Page	2468
Ending Page	2471
File Size	907606
Page Count	4
File Format	PDF
ISBN	9781424479290
ISSN	1557170X
DOI	10.1109/EMBC.2014.6944122
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2014-08-26
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Magnetic resonance imaging Alzheimer's disease Correlation Correlation coefficient Temporal lobe
Content Type	Text
Resource Type	Article
Subject	Signal Processing Biomedical Engineering Health Informatics Computer Vision and Pattern Recognition

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Medial temporal lobe high resolution magnetic resonance images for the early diagnosis of Alzheimer's disease

Anisotropic diffusion filtering for correlated multiple-coil MRI

Reference-guided sparsifying transform design for compressive sensing MRI

Compressed sensing parallel Magnetic Resonance Imaging

A MRI-based platform for catheter navigation

Fast reference based MRI

Identification of Mild Alzheimer's Disease through automated classification of structural MRI features

Highly accelerated dynamic contrast-enhanced MRI with temporal constrained reconstruction

Exploiting similarity in adjacent slices for compressed sensing MRI

Altered small-world anatomical networks in Apolipoprotein-E4 (ApoE4) carriers using MRI

Similar Documents

Medial temporal lobe high resolution magnetic resonance images for the early diagnosis of Alzheimer's disease

Anisotropic diffusion filtering for correlated multiple-coil MRI

Reference-guided sparsifying transform design for compressive sensing MRI

Compressed sensing parallel Magnetic Resonance Imaging

A MRI-based platform for catheter navigation

Fast reference based MRI

Identification of Mild Alzheimer's Disease through automated classification of structural MRI features

Highly accelerated dynamic contrast-enhanced MRI with temporal constrained reconstruction

Exploiting similarity in adjacent slices for compressed sensing MRI

Altered small-world anatomical networks in Apolipoprotein-E4 (ApoE4) carriers using MRI