NDLI: Differences in the cerebral hemodynamics regulation mechanisms of premature infants with intra-ventricular hemorrhage assessed by means of phase rectified signal averaging

Content Provider	IEEE Xplore Digital Library
Author	Caicedo, A. Varon, C. Alderliesten, T. Lemmers, P. van Bel, F. Naulaers, G. Van Huffel, S.
Copyright Year	2014
Description	Author affiliation: Dept. of Electr. Eng., KU Leuven, Leuven, Belgium (Caicedo, A.; Varon, C.; Van Huffel, S.) \|\| Dept. of Neonatology, Univ. Med. Center Utrecht, Utrecht, Netherlands (Alderliesten, T.; Lemmers, P.; van Bel, F.) \|\| Dept. of Neonatology, KU Leuven, Leuven, Belgium (Naulaers, G.)
Abstract	Cerebral hemodynamics regulation consists of several mechanisms that try to keep brain homeostasis. In premature infants, due to the immaturity of their cerebral vascular bed, these mechanisms might be impaired exposing their brain to damage. The status of the cerebral regulation mechanism is classically assessed by measuring the coupling between some systemic variables, such as Mean arterial blood pressure (MABP) and concentration of blood gases, with surrogate measurements for cerebral blood flow, such as brain tissue oxygenation $(rScO_{2})$ measured by means of Near-infrared Spectroscopy. We hypothesized that the coupled dynamics between systemic variables and $rScO_{2}$ is different in premature infants that suffered from brain damage than in those with a favorable clinical outcome. Therefore, we explore the use of phase rectified signal averaging (PRSA) and bi-variate PRSA (BPRSA) in order to identify these differences. We found that the coupled dynamics between changes in MABP and cerebral oxygenation was different in premature infants that suffered III-IV grade intra-ventricular haemorrhage (IVH), when compared to control subjects.
Sponsorship	IEEE Eng. Med. Biol. Soc.
Starting Page	4208
Ending Page	4211
File Size	700078
Page Count	4
File Format	PDF
ISBN	9781424479290
ISSN	1557170X
DOI	10.1109/EMBC.2014.6944552
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2014-08-26
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Hemodynamics Pediatrics Hemorrhaging Blood Ultrasonic variables measurement Couplings Spectroscopy
Content Type	Text
Resource Type	Article
Subject	Signal Processing Biomedical Engineering Health Informatics Computer Vision and Pattern Recognition

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