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62. Efficacy of cathodal transcranial direct current stimulation in drug-resistant epilepsy: A proof of principle
| Content Provider | Semantic Scholar |
|---|---|
| Author | Assenza, Giovanni Campana, Cordero Assenza, Federica Pino, Giovanni Di Lazzaro, Vincenzo Di |
| Copyright Year | 2016 |
| Abstract | It has been proved that Transcranial DCS (tDCS) can modulate cortical excitability, enhancing or decreasing, respectively by anodal or cathodal polarity. The short-term and lasting alterations induced by tDCS are strictly related to the charge density, duration of stimulation and the depth of neuron below the skull. Epilepsy represents a pathophysiological model of unbalanced relation between cortical excitation and inhibition. In this line, tDCS can be exploited to counterbalance the neuronal hyper-excitation through electric neural modulation. This paper aims at providing the efficacy of cathodal tDCS in reducing seizures’ frequency in drug-resistant focal epilepsy. The study was single blind and sham-controlled and compared seizure rate in the 7 days before and after tDCS and after sham in a cross-over design. 9 patients affected by focal resistant epilepsy were enrolled. After tDCS 3 out 9 patients have not any change in seizure rate. 6 patients reduced their seizure frequency >50%. No significant modification were recorded after sham. This study represents the proof that cathodal tDCS may be efficient in reducing seizures’frequency in focal resistant epilepsy. |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/j.clinph.2016.10.074 |
| Volume Number | 127 |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/S1388245716306216 |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/S1388245716306216?dgcid=api_sd_search-api-endpoint |
| Alternate Webpage(s) | https://doi.org/10.1016/j.clinph.2016.10.074 |
| Journal | Clinical Neurophysiology |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
