NDLI: Time and time-frequency analysis of near-infrared signals for the assessment of ozone autohemotherapy long-term effects in multiple sclerosis

Content Provider	IEEE Xplore Digital Library
Author	Lintas, G. Molinari, F. Simonetti, V. Franzini, M. Liboni, W.
Copyright Year	2013
Description	Author affiliation: Un passo insieme ONLUS Found., Turin, Italy (Liboni, W.) \|\| Italian Soc. for Oxygen & Ozone Therapy, Bergamo, Italy (Franzini, M.) \|\| Dept. of Electron. & Telecommun., Politec. di Torino, Turin, Italy (Lintas, G.; Molinari, F.) \|\| Kaos ONLUS Found., Turin, Italy (Simonetti, V.)
Abstract	Ozone autohemotherapy is an emerging therapeutic technique that is gaining increasing importance in treating neurological disorders. A validated and standard methodology to assess the effect of such therapy on brain metabolism and circulation is however still lacking. We used a near-infrared spectroscopy system (NIRS) to monitor the cerebral oxygenation of 9 subjects: 4 remitting-relapsing multiple sclerosis (MS) sufferers and 5 controls. Subjects were tested before, during, and after ozone autohemotherapy. We monitored the concentration changes in the level of oxygenated and deoxygenated haemoglobin, and in the level of the Cytochrome-c-oxidase (CYT-c). From the time and time-frequency analysis of the NIRS signals we extracted 128 variables, which were used to characterize the metabolic brain pattern during the therapy. We showed that by using only 7 NIRS variables out of 128 it is possible to characterize the metabolic brain pattern of the two groups of subjects. The MS subjects showed a marked increase of the CYT-c activity and concentration about 40 minutes after the end of the autohemotherapy, possibly revealing a reduction of the chronic oxidative stress level typical of MS sufferers. From a technical point of view, this preliminary study showed that NIRS could be useful to show the effects of ozone autohemotherapy at cerebral level, in a long term monitoring. The clinical result of this study is the quantitative measurement of the CYT-c level changes in MS induced by ozone autohemotherapy.
Starting Page	6171
Ending Page	6174
File Size	1250443
Page Count	4
File Format	PDF
ISBN	9781457702167
ISSN	1557170X
DOI	10.1109/EMBC.2013.6610962
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2013-07-03
Publisher Place	Japan
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Gases Time-frequency analysis Monitoring Medical treatment Blood Biochemistry Time-domain analysis time-frequency analysis ozone autohemotherapy near-infrared spectroscopy cerebrovascular reactivity
Content Type	Text
Resource Type	Article
Subject	Signal Processing Biomedical Engineering Health Informatics Computer Vision and Pattern Recognition

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