NDLI: Internal inconsistencies in models of electrical stimulation in neural tissue

Content Provider	IEEE Xplore Digital Library
Author	Meffin, H. Tahayori, B. Grayden, D.B. Burkitt, A.N.
Copyright Year	2013
Description	Author affiliation: Dept. of Electr. & Electron. Eng., Univ. of Melbourne, Melbourne, VIC, Australia (Meffin, H.; Tahayori, B.; Grayden, D.B.; Burkitt, A.N.)
Abstract	Calculating the membrane potential of a neurite under extracellular electrical stimulation is important in the design of some recent stimulation strategies for neuroprosthetic devices including retinal implants, cochlear implants, deep brain stimulation. A common approach, widely used in the electrical stimulation literature uses a volume conductor model to calculate the electrical potential in the tissue and then extracts the voltage or current density on the surface of a neuron, which is used as input to the cable equation to calculate the neuron's response. However this approach ignores the effect of the neuron itself as well as surrounding neurons on the extracellular potential. Here we highlight that this leads to an internal inconsistency in the overall model because the result depends on whether the voltage or current density is used to calculate the neural response. The magnitude of this discrepancy is calculated for the example of a point source electrode in a homogeneous medium and is shown to be up to several hundred percent under some stimulus conditions. The inconsistency can be resolved by ensuring that the voltage is related to the current density by the transimpedance of the neurite. Deriving a volume conductor model that satisfies this relationship requires further work.
Starting Page	5946
Ending Page	5949
File Size	351000
Page Count	4
File Format	PDF
ISBN	9781457702167
ISSN	1557170X
DOI	10.1109/EMBC.2013.6610906
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2013-07-03
Publisher Place	Japan
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Electric potential Extracellular Mathematical model Current density Boundary conditions Conductors Equations
Content Type	Text
Resource Type	Article
Subject	Signal Processing Biomedical Engineering Health Informatics Computer Vision and Pattern Recognition

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Electrical stimulation of neural tissue modeled as a cellular composite: Point Source electrode in an isotropic tissue

Boundary integral formulation for the electrical response of a nerve to an extracellular stimulation

External current application in a bidomain model of active neural tissue

Reduction of current density at disk electrode periphery by shaping current pulse edges

A 3D-continuum bidomain model of retinal electrical stimulation using an anatomically detailed mesh

Thermo-electrical equivalents for simulating the electro-mechanical behavior of biological tissue

Fundamental Electrical Quantities in Deep Brain Stimulation: Influence of Domain Dimensions and Boundary Conditions

Parameter exploration of staircase-shape extracellular stimulation for targeted stimulation of myelinated axon

Extracellular stimulation of mouse retinal ganglion cells with non-rectangular voltage-controlled waveforms

Internal inconsistencies in models of electrical stimulation in neural tissue

Similar Documents

Electrical stimulation of neural tissue modeled as a cellular composite: Point Source electrode in an isotropic tissue

Boundary integral formulation for the electrical response of a nerve to an extracellular stimulation

External current application in a bidomain model of active neural tissue

Reduction of current density at disk electrode periphery by shaping current pulse edges

A 3D-continuum bidomain model of retinal electrical stimulation using an anatomically detailed mesh

Thermo-electrical equivalents for simulating the electro-mechanical behavior of biological tissue

Fundamental Electrical Quantities in Deep Brain Stimulation: Influence of Domain Dimensions and Boundary Conditions

Parameter exploration of staircase-shape extracellular stimulation for targeted stimulation of myelinated axon

Extracellular stimulation of mouse retinal ganglion cells with non-rectangular voltage-controlled waveforms

Internal inconsistencies in models of electrical stimulation in neural tissue