NDLI: Measurement of radioactivity concentration in blood by using newly developed ToT LuAG-APD based small animal PET tomograph

Content Provider	IEEE Xplore Digital Library
Author	Malik, A.H. Shimazoe, K. Takahashi, H.
Copyright Year	2013
Description	Author affiliation: Dept. of the Nucl. Eng. & Manage., Univ. of Tokyo, Tokyo, Japan (Malik, A.H.) \|\| Dept. of Nucl. Eng. & Manage., Univ. of Tokyo, Tokyo, Japan (Takahashi, H.) \|\| Dept. of Bio Eng., Univ. of Tokyo, Tokyo, Japan (Shimazoe, K.)
Abstract	In order to obtain plasma time activity curve (PTAC), input function for almost all quantitative PET studies, patient blood is sampled manually from the artery or vein which has various drawbacks. Recently a novel compact Time over Threshold (ToT) based Pr:LuAG-APD animal PET tomograph is developed in our laboratory which has 10% energy resolution, 4.2ns time resolution and 1.76mm spatial resolution. The measured value of spatial resolution shows much promise for imaging the blood vascular, i.e; artery of diameter 2.3-2.4mm, and hence, to measure PTAC for quantitative PET studies. To find the measurement time required to obtain reasonable counts for image reconstruction, the most important parameter is the sensitivity of the system. Usually small animal PET systems are characterized by using a point source in air. We used Electron Gamma Shower 5 (EGS5) code to simulate a point source at different positions inside the sensitive volume of tomograph and the axial and radial variations in the sensitivity are studied in air and phantom equivalent water cylinder. An average sensitivity difference of 34% in axial direction and 24.6% in radial direction is observed when point source is displaced inside water cylinder instead of air.
Starting Page	2453
Ending Page	2456
File Size	556777
Page Count	4
File Format	PDF
ISBN	9781457702167
ISSN	1557170X
DOI	10.1109/EMBC.2013.6610036
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2013-07-03
Publisher Place	Japan
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Positron emission tomography Sensitivity Blood Detectors Time measurement Mathematical model Animals
Content Type	Text
Resource Type	Article
Subject	Signal Processing Biomedical Engineering Health Informatics Computer Vision and Pattern Recognition

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