NDLI: Validation of a multi-scale model of the coronary circulation in adult sheep and newborn lambs

Content Provider	IEEE Xplore Digital Library
Author	Mynard, J.P. Penny, D.J. Smolich, J.J.
Copyright Year	2013
Description	Author affiliation: Heart Res. Group, Murdoch Childrens Res. Inst., Parkville, VIC, Australia (Mynard, J.P.; Penny, D.J.; Smolich, J.J.)
Abstract	We validated a multi-scale model of a left-dominant coronary circulation using high fidelity pressure and flow data acquired in adult sheep and newborn lambs. The model incorporated a one-dimensional representation of the major left conduit coronary arteries, allowing for the study of wave propagation effects. The coronary microvasculature was represented by regional instances of a lumped parameter model consisting of three transmural layers, each with two serial compartments accounting for compliance, resistance and intramyocardial pressure effects. Model inputs comprised measured aortic pressure/flow and ventricular pressure. Minimal data fitting was employed, with only measured mean coronary flow used to iteratively adjust total coronary resistance. The model was adapted to different heart sizes via allometric scaling. Excellent agreement was observed between model and experimental flow waveforms in the proximal circumflex artery, both in terms of the degree of systolic flow impediment and transient waveform features. The proposed multi-scale modelling approach is likely to be useful for studying phasic features of the coronary flow waveform, including coronary waves in different coronary anatomies and throughout development.
Starting Page	3857
Ending Page	3860
File Size	1022234
Page Count	4
File Format	PDF
ISBN	9781457702167
ISSN	1557170X
DOI	10.1109/EMBC.2013.6610386
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2013-07-03
Publisher Place	Japan
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Arteries Heart Pediatrics Adaptation models Transient analysis Blood Myocardium
Content Type	Text
Resource Type	Article
Subject	Signal Processing Biomedical Engineering Health Informatics Computer Vision and Pattern Recognition

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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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