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Content Provider | IEEE Xplore Digital Library |
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Author | Ruijuan Yun Chung-Chih Lin Shuicai Wu Chu-Chung Huang Ching-Po Lin Yi-Ping Chao |
Copyright Year | 2013 |
Description | Author affiliation: Coll. of Life Sci. & Bio-Eng., Beijing Univ. of Technol., Beijing, China (Ruijuan Yun; Shuicai Wu) || Dept. of Comput. Sci. & Inf. Eng., Chang Gung Univ., Taoyuan, Taiwan (Chung-Chih Lin; Yi-Ping Chao) || Inst. of Neurosci., Nat. Yang-Ming Univ., Taipei, Taiwan (Ching-Po Lin) || Inst. of Radiol. Sci., Nat. Yang-Ming Univ., Taipei, Taiwan (Chu-Chung Huang) |
Abstract | In this study, we employed diffusion tensor imaging (DTI) to construct brain structural network and then derive the connection matrices from 96 healthy elderly subjects. The correlation analysis between these topological properties of network based on graph theory and the Cognitive Abilities Screening Instrument (CASI) index were processed to extract the significant network characteristics. These characteristics were then integrated to estimate the models by various machine-learning algorithms to predict user's cognitive performance. From the results, linear regression model and Gaussian processes model showed presented better abilities with lower mean absolute errors of 5.8120 and 6.25 to predict the cognitive performance respectively. Moreover, these extracted topological properties of brain structural network derived from DTI also could be regarded as the bio-signatures for further evaluation of brain degeneration in healthy aged and early diagnosis of mild cognitive impairment (MCI). |
Starting Page | 527 |
Ending Page | 530 |
File Size | 1220114 |
Page Count | 4 |
File Format | |
ISBN | 9781457702167 |
ISSN | 1557170X |
DOI | 10.1109/EMBC.2013.6609553 |
Language | English |
Publisher | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
Publisher Date | 2013-07-03 |
Publisher Place | Japan |
Access Restriction | Subscribed |
Rights Holder | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
Subject Keyword | Predictive models Brain modeling Diffusion tensor imaging Feature extraction Dementia Educational institutions mild cognitive impairment (MCI) Diffusion tensor imaging (DTI) graph theory cognitive abilities screening instrument (CASI) linear regression model Gaussian processes model |
Content Type | Text |
Resource Type | Article |
Subject | Signal Processing Biomedical Engineering Health Informatics Computer Vision and Pattern Recognition |
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