NDLI: Effects of low amplitude pulsed radiofrequency stimulation with different waveform in rats for neuropathic pain

Content Provider	IEEE Xplore Digital Library
Author	Lin, W.T. Chang, C.H. Cheng, C.Y. Chen, M.C. Wen, Y.R. Lin, C.T. Lin, C.W.
Copyright Year	2013
Description	Author affiliation: Grad. Inst. of Biomed. Electron. & Bioinf., Nat. Taiwan Univ., Taipei, Taiwan (Lin, W.T.) \|\| Dept. of Anesthesiology, China Med. Univ. Hosp., Taichung, Taiwan (Wen, Y.R.) \|\| Biomed. Eng., Nat. Taiwan Univ., Taipei, Taiwan (Chang, C.H.; Cheng, C.Y.) \|\| Inst. of Biomed. Eng., Nat. Taiwan Univ., Taipei, Taiwan (Chen, M.C.; Lin, C.W.) \|\| Inst. of Biomed. Electron. & Bioinf., Nat. Taiwan Univ., Taipei, Taiwan (Lin, C.T.)
Abstract	Pulsed-radiofrequency (PRF) electrical stimulation has been widely used for chronic pain treatment. It has been demonstrated with advantages of low temperature over traditional continuous radiofrequency (CRF) lesions with higher amplitude and mono polar electrode to treat pain in clinics (frequency 500 KHz, Pulse duration 20 msec, Amplitude 45 V, Treatment 2 min). We compare the effects of different pulse waveforms and PRF parameters (Pulse duration 25 ms, Treatment duration 5 min, low amplitude of 2.5/1.25 V) with a miniature bi-polar electrode on Dorsal root ganglion (DRG). The pain relief effect due to PRF is evaluated by using Von Frey method for the pain threshold index based on behavior response to mechanical stimulus of various strengths. Experimental results of Von Frey Score show that the sinusoidal group has higher responses than the square wave one. Both fast and secondary expressed proteins of c-fos and pp38 are measured from spinal cord tissue sectioning slides to characterize the pain associated inflammatory responses and their responses due to PRF stimulation.
Starting Page	3590
Ending Page	3593
File Size	949508
Page Count	4
File Format	PDF
ISBN	9781457702167
ISSN	1557170X
DOI	10.1109/EMBC.2013.6610319
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2013-07-03
Publisher Place	Japan
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Radio frequency Electrodes Rats Neuropathic pain Proteins Surgery
Content Type	Text
Resource Type	Article
Subject	Signal Processing Biomedical Engineering Health Informatics Computer Vision and Pattern Recognition

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