NDLI: Sensitivity of MRI for directly detecting neuronal electrical activities in rat brain slices

Content Provider	IEEE Xplore Digital Library
Author	Dongmin Kim Someya, T. Sekino, M.
Copyright Year	2013
Description	Author affiliation: Dept. of Electr. Eng. & Inf. Syst., Univ. of Tokyo, Tokyo, Japan (Dongmin Kim; Someya, T.; Sekino, M.)
Abstract	We developed an experimental setup for magnetic resonance imaging (MRI) of rat brain slices maintained in a hemoglobin-free medium and showed that the MRI system has a sensitivity to magnetic fields of $10^{-11}$ T. The originally developed non-magnetic sample holder consisted of a microelectrode array for recording neuronal potentials and perfusing channels for the medium. Because of the hemoglobin-free condition, the magnetic fields could be distinguished from the baseline signal fluctuations due to hemoglobin. A theoretical estimation of the signal-to-noise ratio showed a sensitivity of 3.3 × $10^{-10}$ T. Parameter optimization using a 7-T MRI system with the developed sample holder resulted in an experimental sensitivity of 4.0 × $10^{-10}$ T. These MRI sensitivities potentially enable us to detect weak magnetic fields arising from neuronal activities, and are sufficiently high for detecting neuronal magnetic fields of 1.4 × $10^{-11}$ T generated in rat brain slices by averaging signals 810 times.
Starting Page	1370
Ending Page	1373
File Size	808865
Page Count	4
File Format	PDF
ISBN	9781457702167
ISSN	1557170X
DOI	10.1109/EMBC.2013.6609764
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2013-07-03
Publisher Place	Japan
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Magnetic resonance imaging Magnetic fields Brain Sensitivity Signal to noise ratio Coils
Content Type	Text
Resource Type	Article
Subject	Signal Processing Biomedical Engineering Health Informatics Computer Vision and Pattern Recognition

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
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