NDLI: Hypnosis control based on the minimum concentration of anesthetic drug for maintaining appropriate hypnosis

Content Provider	IEEE Xplore Digital Library
Author	Furutani, E. Nishigaki, Y. Kanda, C. Takeda, T. Shirakami, G.
Copyright Year	2013
Description	Author affiliation: Chubu Electr. Power Co. Inc., Nagoya, Japan (Nishigaki, Y.) \|\| Dept. of Anesthesiology, Kagawa Univ., Kagawa, Japan (Takeda, T.; Shirakami, G.) \|\| Dept. of Electr. Eng., Kyoto Univ., Kyoto, Japan (Furutani, E.; Kanda, C.)
Abstract	This paper proposes a novel hypnosis control method using Auditory Evoked Potential Index (aepEX) as a hypnosis index. In order to avoid side effects of an anesthetic drug, it is desirable to reduce the amount of an anesthetic drug during surgery. For this purpose many studies of hypnosis control systems have been done. Most of them use Bispectral Index (BIS), another hypnosis index, but it has problems of dependence on anesthetic drugs and nonsmooth change near some particular values. On the other hand, aepEX has an ability of clear distinction between patient consciousness and unconsciousness and independence of anesthetic drugs. The control method proposed in this paper consists of two elements: estimating the minimum effect-site concentration for maintaining appropriate hypnosis and adjusting infusion rate of an anesthetic drug, propofol, using model predictive control. The minimum effect-site concentration is estimated utilizing the property of aepEX pharmacodynamics. The infusion rate of propofol is adjusted so that effect-site concentration of propofol may be kept near and always above the minimum effect-site concentration. Simulation results of hypnosis control using the proposed method show that the minimum concentration can be estimated appropriately and that the proposed control method can maintain hypnosis adequately and reduce the total infusion amount of propofol.
Starting Page	3483
Ending Page	3486
File Size	270406
Page Count	4
File Format	PDF
ISBN	9781457702167
ISSN	1557170X
DOI	10.1109/EMBC.2013.6610292
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2013-07-03
Publisher Place	Japan
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Estimation Anesthetic drugs Indexes Control systems Accuracy Surgery
Content Type	Text
Resource Type	Article
Subject	Signal Processing Biomedical Engineering Health Informatics Computer Vision and Pattern Recognition

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