NDLI: Characterization of liquid jet injection into tissue based on optical coherence tomography

Content Provider	IEEE Xplore Digital Library
Author	Mutschler, K. Tanguy, L. Weber, N. Ernst, A. Zengerle, R. Koltay, P.
Copyright Year	2013
Description	Author affiliation: Inst. fur Mikro- und Informationstechnik, HSG-IMIT, Freiburg, Germany (Tanguy, L.) \|\| Dept. of Micro-Opt., Univ. of Freiburg, Freiburg, Germany (Weber, N.) \|\| Lab. for MEMS Applic., Univ. of Freiburg, Freiburg, Germany (Mutschler, K.; Ernst, A.; Zengerle, R.; Koltay, P.)
Abstract	We present the combination of high speed video monitoring, force measurement and Optical Coherence Tomography (OCT) as a new method for the characterization of liquid jets for needle-free tissue injection applications. It is well known that physical parameters, such as jet velocity and jet diameter determine the penetration characteristics of liquid micro-jets into a specific tissue [1]. The optimum injection parameters vary significantly for different types of tissues. Therefore, we have used high speed video monitoring and force sensor measurements to characterize the liquid jet. The penetration into the tissue is then analyzed by Optical Coherence Tomography (OCT) [2]. This enables the general description of the specific jet's physical properties as well as the penetration characteristics with respect to a specific tissue. In the experimental study, jets with diameters of 100 μm and jet lengths from 6 to 18 ms (~ 2 to 9 μl) have been injected into colon tissue from pigs.
Starting Page	1675
Ending Page	1678
File Size	2262497
Page Count	4
File Format	PDF
ISBN	9781467359832
ISSN	21641641
DOI	10.1109/Transducers.2013.6627107
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2013-06-16
Publisher Place	Spain
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Force Valves Manganese Liquids Colon Force measurement Optical sensors penetration of tissue Needle-free jet injection micro fluidics optical coherence tomography
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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