NDLI: A new MEMS neural probe integrated with embedded microfluidic channel for drug delivery and electrode array for recording neural signal

Content Provider	IEEE Xplore Digital Library
Author	Yanghee Kim Lee, H.J. Dohee Kim Yun Kyung Kim Soo Hyun Lee Eui-Sung Yoon Il-Joo Cho
Copyright Year	2013
Description	Author affiliation: Center for Neuro-Med., Korea Inst. of Sci. & Technol., Seoul, South Korea (Dohee Kim; Yun Kyung Kim) \|\| Center for BioMicrosystems, Korea Inst. of Sci. & Technol., Jeonju, South Korea (Yanghee Kim; Lee, H.J.; Soo Hyun Lee; Eui-Sung Yoon; Il-Joo Cho)
Abstract	We present a multi-functional silicon neural probe that consists of a microfluidic channel for selective delivery of a precise quantity of a chemical and multiple recording electrodes to simultaneously monitor the effects of drug delivery. A 30-μm wide, 10-μm high microfluidic channel is embedded in the probe substrate by anodic bonding, thermal reflowing and polishing a glass wafer to seal the channel. 10-μm-by-10-μm four multiple recording sites are located near the outlet port to record neural spike signals in response to the delivered drug. The fabricated 150-μm-thick probe exhibits a flow rate of 0.2 μl/min at the input air pressure of 200 kPa and an average impedance value of 3.0 MΩ at 1 kHz. In addition, the functionality of this probe is demonstrated through an in vivo experiment where neural spike signals at the hippocampus of an anesthetized mouse are successfully detected and recorded.
Starting Page	876
Ending Page	879
File Size	1168667
Page Count	4
File Format	PDF
ISBN	9781467359832
ISSN	21641641
DOI	10.1109/Transducers.2013.6626907
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2013-06-16
Publisher Place	Spain
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Probes Microfluidics Glass Drug delivery Silicon Electrodes Chemicals integrated silicon MEMS probe Neural probe drug delivery chemical stimulation
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
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