NDLI: An electrokinetically controlled microchip for studying binding interactions of nucleic acids with cells

Content Provider	IEEE Xplore Digital Library
Author	Kim, J. Hilton, J.P. Yang, K. Pei, R. Stojanovic, M. Lin, Q.
Copyright Year	2013
Description	Author affiliation: Med., Columbia Univ., New York, NY, USA (Yang, K.; Pei, R.; Stojanovic, M.) \|\| Depts. of Mech. Eng., Columbia Univ., New York, NY, USA (Kim, J.; Hilton, J.P.; Lin, Q.)
Abstract	This paper presents an electrokinetically controlled microfluidic chip that allows investigation of binding interactions between nucleic acids and target cells. The microchip consists of two microchambers for capture of cells using an integrated microweir structure and collection of DNA strands, respectively. The chambers are connected by a microchannel filled with agarose gel. In the chip, nucleic acids that interact with target cells are electrokinetically separated and isolated from the cells through the gel-filled channel for subsequent analysis. Experimental results demonstrate that our microchip can potentially be used for studying interactions of nucleic acids with target cells in practical biomedical applications.
Starting Page	1190
Ending Page	1193
File Size	1056142
Page Count	4
File Format	PDF
ISBN	9781467359832
ISSN	21641641
DOI	10.1109/Transducers.2013.6626986
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2013-06-16
Publisher Place	Spain
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	DNA Cells (biology) Electric fields Microfluidics Fluorescence Electric potential System-on-chip MCF-7 cells Microfluidic chip electrophoresis nucleic acids aptamers
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
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9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

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