NDLI: Microfluidic device to perform impedometric detection of Activated Partial Thromboplastin Time of blood

Content Provider	IEEE Xplore Digital Library
Author	Ramaswamy, B. Yeh, Y.T. Zheng, S.Y.
Copyright Year	2011
Description	Author affiliation: Department of Electrical Engineering, The Pennsylvania State University, University Park, U.S.A (Ramaswamy, B.) \|\| MINIBio Lab, Department of Bioengineering, The Pennsylvania State University, University Park, U.S.A (Yeh, Y.T.; Zheng, S.Y.)
Abstract	The Activated Partial Thromboplastin Time (APTT) test is performed on a large scale, in laboratories to monitor the functioning of intrinsic and common pathways of blood coagulation cascade and the concentration of anticoagulants such as Heparin among patients. A PDMS based microfluidic device has been fabricated and tested to perform APTT as a point-of-care device using whole blood samples by detecting the change in electrical impedance of blood during coagulation. The two chambered PDMS device integrated with microelectrodes is pre-coated with APTT reagent and heparin respectively for better repeatability. The results indicate a repeatable pattern of change in whole blood impedance during coagulation and confirm the theoretical explanation by Hartert [1]. The devices were also tested for their sensitivity to different concentrations of heparin and found to exhibit a favorable increase in coagulation time for increasing heparin concentration.
Starting Page	222
Ending Page	225
File Size	983596
Page Count	4
File Format	PDF
ISBN	9781457701573
e-ISBN	9781457701566
DOI	10.1109/TRANSDUCERS.2011.5969391
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2011-06-05
Publisher Place	China
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Coagulation Impedance Monitoring Laboratories Performance evaluation Surface treatment Blood impedance measurement Blood coagulation APTT test
Content Type	Text
Resource Type	Article

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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