NDLI: A high-performance microsystem for isolating viable circulating tumor cells

Content Provider	IEEE Xplore Digital Library
Author	Zheng, X.J. Cheung, L.S.L. Schroeder, J.A. Jiang, L. Zohar, Y.
Copyright Year	2011
Description	Author affiliation: Dept. Molecular and Cellular Biology, The University of Arizona, Tucson, USA (Schroeder, J.A.) \|\| Dept. Aerospace and Mechanical Engineering, The University of Arizona, Tucson, USA (Zheng, X.J.; Cheung, L.S.L.; Jiang, L.; Zohar, Y.)
Abstract	The attachment and detachment of target cancer cells from homogeneous and binary mixtures in antibody-functionalized microchannels have been studied experimentally. Under the same intermediate flow rate, the attachment rate was found to be higher, and detachment flow rate was lower, for cell lines expressing the target receptor at a higher level. For cells that do not express the target receptor, the attachment rate was much lower but did not diminish, due to non-specific binding, and the detachment rate was much higher. The bio-functional microfluidic system performance in selectively isolating target cells from binary mixtures is quantitatively characterized. While the system sensitivity is typically very high, almost 100%, the specificity is lower than 90%. Applying a unique flow scheme of a slow flow rate, for maximum capture of target cells, followed by a faster flow rate, for maximum removal of non-target cells, the specificity is enhanced to levels above 95%, even for mixtures with target cells present at 1∶1,000 relative concentration ratio.
Starting Page	226
Ending Page	229
File Size	668203
Page Count	4
File Format	PDF
ISBN	9781457701573
e-ISBN	9781457701566
DOI	10.1109/TRANSDUCERS.2011.5969382
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2011-06-05
Publisher Place	China
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Microchannel Sensitivity Suspensions Microfluidics Breast cancer Silicon cell isolation Circulating tumor cells Specificity Microchannels
Content Type	Text
Resource Type	Article

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