NDLI: Label-free DNA detection based on silicon nanowires

Content Provider	IEEE Xplore Digital Library
Author	Gao, A.R. Lu, N. Gao, X.L. Dai, P.F. Li, T. Gong, Y.B. Fan, C.H. Wang, Y.L.
Copyright Year	2011
Description	Author affiliation: State Key Laboratories of Transducer Technology, Science and Technology on Micro-system Laboratory, Shanghai Institute of Microsystem and Information Technology, CAS, China (Gao, A.R.; Gao, X.L.; Dai, P.F.; Li, T.; Gong, Y.B.; Wang, Y.L.) \|\| Shanghai Institute of Applied Physics, Chinese Academy of Sciences, China (Lu, N.; Fan, C.H.)
Abstract	Based on silicon nanowires (SiNWs) fabricated by MEMS technology, highly sensitive, sequence-specific and label-free DNA sensors were demonstrated in this paper. Optical lithography and anisotropic self-stop etching were employed to guarantee low cost batch production for SiNWs. Amine-functionalized SiNWs exhibit pH-dependent linear current over a wide range. SiNWs with chemically functionalized single-stranded DNA can recognize the complementary DNA at pM range. In contrast, there is no current change for non-complementary DNA even at a high concentration. With small size and potential for mass production, SiNWs can be potentially developed to become a portable biosensor.
Starting Page	2271
Ending Page	2274
File Size	632534
Page Count	4
File Format	PDF
ISBN	9781457701573
e-ISBN	9781457701566
DOI	10.1109/TRANSDUCERS.2011.5969329
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2011-06-05
Publisher Place	China
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	DNA Nanowires Silicon Sensors Probes Voltage measurement Real time systems SiNWs FET label-free
Content Type	Text
Resource Type	Article

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