NDLI: Thermal Performance Analysis of a Silicon Microreactor for Rapid DNA Analysis

Content Provider	IEEE Xplore Digital Library
Author	Kumar Gnanappa, A. Ke, C. Slattery, O. Sheehan, M.
Copyright Year	2006
Description	Author affiliation: Tyndall Nat. Inst., Cork (Kumar Gnanappa, A.; Ke, C.; Slattery, O.; Sheehan, M.)
Abstract	This paper describes the use of thermal modelling tools in the design and characterisation of a multi-function silicon microreactor polymerase chain reaction (PCR) thermocycler system for rapid DNA diagnostic assays. MEMS technologies have been successfully applied to this application and the miniaturization of devices offers several advantages; including reduced assay times, reduced amounts of expensive reagents required as well as allowing rapid heating/cooling rates due to the lower thermal mass. This technique involves repetitive cycling at three different temperatures and requires rapid and accurate temperature changes. However, the direct measurement and monitoring of the temperature distribution on the nanostructures is still a challenge. Thus, this paper describes the use of static and transient thermal modeling to analyse the thermal performance of the system. The CFD code Flotherm was used to construct a 3D model of the PCR system. The system included assisted fan cooling in the thermal cycling chamber. Static thermal analysis was undertaken to simulate the temperature profile within the overall system and thus determine the fan characteristics needed to maintain system temperatures within operating requirements. Secondly, the PCR system operation involves repetitive thermal cycling of DNA at three different temperatures and requires rapid and accurate temperature changes. The thermal modeling results were used to determine the input power levels needed to obtain this required temperature/time profile
Starting Page	1330
Ending Page	1335
File Size	591121
Page Count	6
File Format	PDF
ISBN	0780395247
ISSN	10879870
DOI	10.1109/ITHERM.2006.1645499
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2006-05-30
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Performance analysis Silicon DNA Cooling Polymers Micromechanical devices Heating Temperature measurement Temperature sensors Temperature distribution
Content Type	Text
Resource Type	Article

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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