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| Content Provider | IEEE Xplore Digital Library |
|---|---|
| Author | Lin, Yu-Cheng |
| Copyright Year | 2009 |
| Description | Author affiliation: Royal Society of Chemistry (UK) (Lin, Yu-Cheng) |
| Abstract | Polydimethylsiloxane (PDMS) microfluidic chips with various cross-junction angles were designed and fabricated by MEMS and soft lithography technologies to construct chitosan microfibers. Chitosan solution and sodium tripolyphosphate (STPP) solution were injected into the cross-junction microchannel of the microfluidic chip, which generated the laminar flow of chitosan solution by the hydrodynamic focusing. Cross-junction microchannels with angle 30°、45° and 60° were designed to investigate the generation of laminar flow. The microchannel of angle 30° could produce smaller diameter of chitosan laminar flow than the other angles at the fixed flow rates. Different diameters of laminar flow from 15 µm to 40 µm were successfully generated and transformed into the chitosan microfibers using STPP solution, with the range of chitosan microfiber diameter from 20 µm to 50 µm. The schwann cells and fibroblast cells were employed for cell culture in chitosan microfibers, which would be applied in tissue engineering as scaffold. |
| File Size | 603784 |
| File Format | |
| ISBN | 9781424446292 |
| DOI | 10.1109/NEMS.2009.5068790 |
| Language | English |
| Publisher | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Publisher Date | 2009-01-05 |
| Publisher Place | China |
| Access Restriction | Subscribed |
| Rights Holder | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Subject Keyword | Microfluidics Microchannel Systems engineering and theory Chemistry Design engineering Micromechanical devices Soft lithography Chemical technology Hydrodynamics Fibroblasts |
| Content Type | Text |
| Resource Type | Article |
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