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| Content Provider | IEEE Xplore Digital Library |
|---|---|
| Author | Gidwani, V. Yi Lu Zhang, D.D. Pak Kin Wong |
| Copyright Year | 2009 |
| Description | Author affiliation: Department of Pharmacology and Toxicology, University of Arizona, USA (Zhang, D.D.) || Department of Aerospace and Mechanical Engineering, University of Arizona, USA (Pak Kin Wong) || Department of Biochemistry and Molecular Biophysics, University of Arizona, USA (Gidwani, V.) || Department of Computer Science, University of Arizona, USA (Yi Lu) |
| Abstract | The ingestion of some organic compounds has been known to lower the risk of cancer. With emerging studies in the past decade, the biological effect of these compounds has been recognized within a clinical context and presents an appealing strategy for cancer prevention. These compounds, now commonly referred as chemopreventive agents or anti-carcinogens, often exert their activity by inducing expression of phase II enzymes and endogenous antioxidants via the Nrf2 signaling pathway, which defends cells from harmful oxidative stress and reactive carcinogenic intermediates. Here, we present several micro- and nanoscale technological modularities, including two molecular assays and a multiplexed microfluidic device, toward the creation of a nanoengineered platform for high-throughput screening of chemopreventive compounds targeting Nrf2. The ability to rapidly identify agents that can prevent the occurrence and reduce the severity of cancer is of great importance in the management of cancer and represents a pathway toward the realization of preventive medicine. |
| Starting Page | 832 |
| Ending Page | 836 |
| File Size | 7058743 |
| Page Count | 5 |
| File Format | |
| ISBN | 9781424446292 |
| DOI | 10.1109/NEMS.2009.5068705 |
| Language | English |
| Publisher | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Publisher Date | 2009-01-05 |
| Publisher Place | China |
| Access Restriction | Subscribed |
| Rights Holder | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Subject Keyword | Cancer USA Councils Probes Nanobioscience Degradation High temperature superconductors Sequences Biochemistry Nanoscale devices Switches chemoprevention Nrf2 drug screening molecular sensors cancer |
| Content Type | Text |
| Resource Type | Article |
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