NDLI: An Open-configuration Electrowetting-based Biofluidics Actuation for Preventing Biomolecular Adsorption

Content Provider	IEEE Xplore Digital Library
Author	Jiangang Wu Ruifeng Yue Xuefeng Zeng Ming Kang Zheyao Wang Litian Liu
Copyright Year	2006
Description	Author affiliation: Inst. of Microelectron., Beijing Tsinghua Univ. (Jiangang Wu; Ruifeng Yue; Xuefeng Zeng; Ming Kang; Zheyao Wang; Litian Liu)
Abstract	Electrowetting-on-dielectric (EWOD) is a new method for moving liquids in micro-total-analysis system. One of the biggest challenges for all EWOD-based biofluidic chips is preventing and minimizing nonspecific adsorption of biomolecules on the hydrophobic surfaces. In this paper, we theoretically and experimentally analyze the adsorption in EWOD, which is mainly induced by hydrophobic interaction and electrostatic attraction. An open-configuration EWOD with only one hydrophobic surface, instead of the traditional sandwiched EWOD with two hydrophobic surfaces, is exploited to minimize the hydrophobic interaction. The manipulation modes are also optimized to decrease electrostatic attraction by limiting the duty-ratio of the applied pulse voltage. In experiments, the analyte is a 1:1 (v/v) mixture of 10 mug/ml bovine serum albumin (BSA) solution with pH 7.4 phosphate buffers and 10 mug/ml hen egg white lysozyme solution with pH 7.4 phosphate buffers. A rapid transportation speed of the 1.5 mul mixture droplet as high as 14 mm/s is successfully achieved in air by applying a 2.5 Hz 40 $V_{dc}$ pulse voltage with the 12.5% duty-ratio. The fabrication process of the silicon-substrate actuator is IC compatible, thus a miniaturized biofluidic system integrated with peripheral circuits is technically feasible
Starting Page	1152
Ending Page	1155
File Size	4475280
Page Count	4
File Format	PDF
ISBN	1424401399
DOI	10.1109/NEMS.2006.334669
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2006-01-18
Publisher Place	China
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Molecular biophysics Voltage Electrostatics Liquids Fabrication Equations Dielectric constant Proteins Petroleum Electrodes biofluidics biomolecular adsorption electrowetting
Content Type	Text
Resource Type	Article

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