NDLI: The Therapeutic Effect of Nanosized As2O3/Fe3O4 Complex in Combination with Magnetic Fluid Hyperthermia(MFH) on Cervical Cancer

Content Provider	IEEE Xplore Digital Library
Author	Yiqun Du Dongsheng Zhang Haiyan Ni
Copyright Year	2006
Description	Author affiliation: Dept. of Pathology & Pathophysiology, Southeast Univ., Nanjing, PA (Yiqun Du; Dongsheng Zhang; Haiyan Ni)
Abstract	The objective of this paper is to study the therapeutic effect of nanosized $As_{2}O_{3}/Fe_{3}O_{4}$ complex $(Fe_{3}O_{4}$ magnetic nanoparticles containing $As_{2}O_{3})$ combined with magnetic fluid hyperthermia (MFH) on human cervical cancer Hela cells in vitro and xenograft cervical cancer in nude mice. The growth and apoptosis of Hela cells treated with nanosized $As_{2}O_{3}/Fe_{3}O_{4$complex combined with MFH was examined by MTT, Flow cytometry assay and transmission electron microscopy (TEM) in vitro. We also observed mass and volume inhibitory rates of the tumors of Hela-bearing nude mice by using animal experiment. The results indicated that the nanosized $As_{2}O_{3}/Fe_{3}O_{4}$ complex combined with MFH could significantly inhibit the proliferation and induce apoptosis of Hela cells. The inhibitory rate was 61.43%, the apoptotic indexes was 44.79%. Animal experiments showed that the mass inhibitory ratio of the tumors treated with $As_{2}O_{3}/Fe_{3}O_{4}$ complex combined with MFH was 88.21%, and the volume inhibitory ratio was 91.57%. Compared with the control and experimental groups, each group had statistically significant difference (p < 0.05). So, $As_{2}O$ $_{3}/Fe_{3}O_{4}$ complex combined with MFH could inhibit the proliferation and induce apoptosis of Hela cells and also has a conspicuous inhibitory effect on the weight and volume of xenograft cervical cancer
Starting Page	343
Ending Page	348
File Size	7808374
Page Count	6
File Format	PDF
ISBN	1424401399
DOI	10.1109/NEMS.2006.334755
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2006-01-18
Publisher Place	China
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Magnetic liquids Hyperthermia Cervical cancer Iron In vitro Mice Neoplasms Animals Nanoparticles Humans xenograft tumor nanosized As2O3Fe3O4 complex magnetic fluid hyperthermia cervical cancer
Content Type	Text
Resource Type	Article

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