NDLI: Discrete cortical responses from multi-site supra-choroidal electrical stimulation in the feline retina

Content Provider	IEEE Xplore Digital Library
Author	Suaning, G.J. Kisban, S. Chen, S.C. Byrnes-Preston, P.J. Dodds, C. Tsai, D. Matteucci, P. Herwik, S. Morley, J.W. Lovell, N.H. Paul, O. Stieglitz, T. Ruther, P.
Copyright Year	2010
Description	Author affiliation: Graduate School of Biomedical Engineering, University of New South Wales, Sydney 2052, Australia (Suaning, G.J.; Byrnes-Preston, P.J.; Dodds, C.; Tsai, D.; Matteucci, P.; Lovell, N.H.) \|\| School of Psychiatry, University of New South Wales, Sydney 2052, Australia (Chen, S.C.) \|\| Department of Microsystems Engineering (IMTEK), University of Freiburg, D-79110, Germany (Kisban, S.; Herwik, S.; Paul, O.; Stieglitz, T.; Ruther, P.) \|\| School of Medicine, University of Western Sydney, Campbelltown, Australia (Morley, J.W.)
Abstract	Exploration into electrical stimulation of the retina has thus far focussed primarily upon the development of prostheses targeted at one of two sites of intervention - the epi- and sub-retinal surfaces. These two approaches have sound, logical merit owing to their proximity to retinal neurons and their potential to deliver stimuli via the surviving retinal neural networks respectively. There is increasing evidence, however, that electric field effects, electrode engineering limitations, and electrode-tissue interactions limit the spatial resolution that once was hoped could be elicited from electrical stimulation at epi- and sub-retinal sites. An alternative approach has been proposed that places a stimulating electrode array within the supra-choroidal space - that is, between the sclera and the choroid. Here we investigate whether discrete, cortical activity patterns can be elicited via electrical stimulation of a feline retina using a custom, 14 channel, silicone rubber and Pt electrode array arranged in two hexagons comprising seven electrodes each. Cortical responses from Areas 17/18 were acquired using a silicon-based, multi-channel, penetrating probe developed at IMTEK, University of Freiburg, within the European research project NeuroProbes. Multi-unit spike activity was recorded in synchrony with the presentation of electrical stimuli. Results show that distinct cortical response patterns could be elicited from each hexagon separated by 1.8 mm (center-to-center) with a center-to-center electrode spacing within each hexagon of 0.55 mm. This lends support that higher spatial resolution may also be discerned.
Starting Page	5879
Ending Page	5882
File Size	1861241
Page Count	4
File Format	PDF
ISBN	9781424441235
ISSN	1557170X
DOI	10.1109/IEMBS.2010.5627527
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2010-08-31
Publisher Place	Argentina
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Electrodes Arrays Retina Probes Visualization Animals Electric potential
Content Type	Text
Resource Type	Article
Subject	Signal Processing Biomedical Engineering Health Informatics Computer Vision and Pattern Recognition

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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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