NDLI: Activation of ganglion cell axons following epiretinal electrical stimulation with hexagonal electrodes

Content Provider	IEEE Xplore Digital Library
Author	Abramian, M. Dokos, S. Morley, J.W. Lovell, N.H.
Copyright Year	2010
Description	Author affiliation: Graduate School of Biomedical Engineering. The University of New South Wales, Sydney, Australia (Abramian, M.; Dokos, S.; Lovell, N.H.) \|\| School of Medicine, University of Western Sydney, Campbelltown, Australia (Morley, J.W.)
Abstract	A hexagonal electrode configuration has been proposed as an advantageous alternative to conventional electrode arrangements used in retinal prosthesis design. In the present study, the aim was to characterize retinal ganglion cell axonal responses to epiretinal electrical stimulation. 50 and 125 µm disk electrodes, arranged in a hexagonal configuration, were tested using in vitro rabbit retinal preparations. 100 µs/phase anodic-first biphasic current pulses were applied to the inner retinal surface, and ganglion cell responses were recorded differentially with extracellular microelectrodes. Axonal activation thresholds were 4.7±2.5 µA for 50 µm, and 9.3±4.0 µA for 125 µm electrodes. With anodic monophasic pulses there was a 3.3±0.8 times increase in threshold, compared to anodic-first biphasic stimulation. Thresholds increased up to 20 times when stimulating electrodes were lifted 100 µm above the retinal surface. Overall, axonal activation thresholds were within the safe charge injection limits for platinum electrodes, given that these electrodes were positioned in close proximity to the retinal surface.
Starting Page	6753
Ending Page	6756
File Size	637075
Page Count	4
File Format	PDF
ISBN	9781424441235
ISSN	1557170X
DOI	10.1109/IEMBS.2010.5626002
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2010-08-31
Publisher Place	Argentina
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Electrodes Retina Electrical stimulation Nerve fibers Electric potential Extracellular Rabbits
Content Type	Text
Resource Type	Article
Subject	Signal Processing Biomedical Engineering Health Informatics Computer Vision and Pattern Recognition

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