NDLI: Time-varying analysis of autonomic control in response to spontaneous sighs in sickle cell anemia

Content Provider	IEEE Xplore Digital Library
Author	Sangkatumvong, S. Coates, T.D. Wood, J.C. Meiselman, H.J. Kato, R. Detterich, J.A. Bush, A. Khoo, M.C.K.
Copyright Year	2010
Description	Author affiliation: Keck School of Medicine, University of Southern California, Los Angeles, 90089 USA (Meiselman, H.J.) \|\| Childrens Hospital Los Angeles, CA 90027 USA (Coates, T.D.; Wood, J.C.; Kato, R.; Detterich, J.A.; Bush, A.) \|\| Biomedical Engineering Department, University of Southern California, Los Angeles, 90089 USA (Sangkatumvong, S.; Khoo, M.C.K.)
Abstract	Sickle cell anemia (SCA) is a genetic disease which is characterized by painful episodes of vascular occlusions. In the present study, we investigated a potential contribution of the autonomic nervous system (ANS) in initiating such episodes. We observed prominent decreases in microvascular perfusion in response to spontaneous sighs, which may increase the likelihood of red blood cell polymerization followed by vascular occlusions in SCA patients. Time-varying spectral analysis of heart rate variability (HRV), based on recursive least squares estimation, was employed to study the modulation of the ANS in response to sighs. To improve robustness of the spectral estimation while retaining its ability to track rapid changes, we propose a time-varying parameter estimate variability reduction (TV-PEVR) technique. Because respiration patterns can vary considerably across subjects, we employed a time-varying autoregressive with exogenous input (TV-ARX) model to adjust for the effect of respiration patterns on the HRV indices. Results from 8 SCA subjects and 9 normal controls suggested that the cardiac ANS responses to sighs are not different between the two groups, after adjusting for the effect of post-sigh respiration. However, the peripheral sympathetic response in SCA appeared to be enhanced in this group relative to normals, and sighs may play a role in initiation of vaso-occlusive events in this group of patients.
Starting Page	1626
Ending Page	1629
File Size	489909
Page Count	4
File Format	PDF
ISBN	9781424441235
ISSN	1557170X
DOI	10.1109/IEMBS.2010.5626649
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2010-08-31
Publisher Place	Argentina
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Heart rate variability Rail to rail inputs Estimation Mathematical model Modulation Time frequency analysis Pediatrics
Content Type	Text
Resource Type	Article
Subject	Signal Processing Biomedical Engineering Health Informatics Computer Vision and Pattern Recognition

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