NDLI: Multiple-Model Set-Valued Observers: A new tool for HRF model selection in fMRI

Content Provider	IEEE Xplore Digital Library
Author	Silvestre, C. Figueiredo, P. Rosa, P.
Copyright Year	2010
Description	Author affiliation: Institute for Systems and Robotics - Instituto Superior Tecnico, Av. Rovisco Pais, 1, 1049-001 Lisboa, Portugal (Silvestre, C.; Figueiredo, P.; Rosa, P.)
Abstract	This paper proposes a new approach for the selection of a biophysical model describing the haemodynamic response function (HRF) measured in BOLD-fMRI data, based on model falsification techniques. Specifically, the novel method of Multiple Model Set-Valued Observers (MMSVOs) is introduced. The observers consider that the initial state lives in a set, the linear time-varying dynamic system obtained from a bilinear approximation of the nonlinear HRF model about the nominal input signal is uncertain, and the output measurements are corrupted by bounded noise. It is shown, both theoretically and through simulation, that the proposed method is able to successfully distinguish the correct HRF model among a set of physiologically plausible alternatives. Moreover, the feasibility of the technique is demonstrated by its application to an empirical dataset. In summary, the results obtained clearly indicate that the proposed methodology is potentially well-suited to be used in the modeling of BOLD-fMRI data.
Starting Page	5704
Ending Page	5707
File Size	365880
Page Count	4
File Format	PDF
ISBN	9781424441235
ISSN	1557170X
DOI	10.1109/IEMBS.2010.5627877
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2010-08-31
Publisher Place	Argentina
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Data models Noise Observers Silicon Noise measurement Blood Mathematical model
Content Type	Text
Resource Type	Article
Subject	Signal Processing Biomedical Engineering Health Informatics Computer Vision and Pattern Recognition

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3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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