NDLI: Development of a toxin screening multi-parameter on-line biochip system ‘Toxichip’

Content Provider	IEEE Xplore Digital Library
Author	Moore, E.
Copyright Year	2010
Description	Author affiliation: Life Science Interface, Tyndall National Institute, Lee Maltings, University College Cork, Ireland (Moore, E.)
Abstract	The development of a cell based biochip-sensing platform that examines the effects of toxic chemicals both electrically and optically is presented. The name of this sensing platform is called Toxichip. Toxichip aims to develop and promote alternative novel in-vitro testing methods for the monitoring of a vast array of toxins, thus alleviating the current demand for animal sacrifice while also permitting high throughput screening. Cell-based biosensors (CBBs), which treat living cells as sensing elements, are able to detect the functional information of biologically active analytes and also provide quantitative analysis. In general, they maintain living cells and observe the cellular physiological response after subjecting cells to toxin stimuli and verify the presence and the concentration of these stimuli. CBBs characterise with high sensitivity, excellent selectivity and a fast response time. There has been increased interest in the use of microelectronic biosensors that allow cellular activity to be analysed in vitro.
Starting Page	302
Ending Page	304
File Size	743747
Page Count	3
File Format	PDF
ISBN	9781424441235
ISSN	1557170X
DOI	10.1109/IEMBS.2010.5627524
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2010-08-31
Publisher Place	Argentina
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Optical sensors Impedance Monitoring Optical imaging Surface morphology Surface impedance
Content Type	Text
Resource Type	Article
Subject	Signal Processing Biomedical Engineering Health Informatics Computer Vision and Pattern Recognition

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