NDLI: Terahertz sensing of corneal hydration

Content Provider	IEEE Xplore Digital Library
Author	Singh, R.S. Tewari, P. Bourges, J.L. Hubschman, J.P. Bennett, D.B. Taylor, Z.D. Lee, H. Brown, E.R. Grundfest, W.S. Culjat, M.O.
Copyright Year	2010
Description	Author affiliation: UCLA Departments of Bioengineering and Surgery, UCSB Department of Electrical and Computer Engineering, Los Angeles, CA 90095 USA (Culjat, M.O.) \|\| CASIT and the UCLA Department of Electrical Engineering, USA (Bennett, D.B.) \|\| Wright State University Department of Electrical Engineering, Dayton, OH 45435, USA (Brown, E.R.) \|\| UCSB Electrical and Computer Engineering Department, Santa Barbara, CA 93106 USA (Lee, H.) \|\| UCLA Department of Surgery, UCSB Department of Electrical and Computer Engineering, Los Angeles, CA 90095 USA (Singh, R.S.) \|\| CASIT and the UCLA Departments of Ophthalmology, Los Angeles, CA 90095, USA (Hubschman, J.P.) \|\| CASIT and the UCLA Departments of Bioengineering, Electrical Engineering, and Surgery, Los Angeles, CA 90095 USA (Grundfest, W.S.) \|\| CASIT and the UCLA Biomedical Engineering IDP, Los Angeles, CA 90095 USA (Tewari, P.; Taylor, Z.D.) \|\| UCLA Department of Ophthalmology, Los Angeles, CA 90095, USA (Bourges, J.L.)
Abstract	An indicator of ocular health is the hydrodyanmics of the cornea. Many corneal disorders deteriorate sight as they upset the normal hydrodynamics of the cornea. The mechanisms include the loss of endothelial pump function of corneal dystophies, swelling and immune response of corneal graft rejection, and inflammation and edema, which accompany trauma, burn, and irritation events. Due to high sensitivity to changes of water content in materials, a reflective terahertz (300 GHz and 3 THz) imaging system could be an ideal tool to measure the hydration level of the cornea. This paper presents the application of THz technology to visualize the hydration content across ex vivo porcine corneas. The corneas, with a thickness variation from 470 - 940 µm, were successfully imaged using a reflective pulsed THz imaging system, with a maximum SNR of 50 dB. To our knowledge, no prior studies have reported on the use of THz in measuring hydration in corneal tissues or other ocular tissues. These preliminary findings indicate that THz can be used to accurately sense hydration levels in the cornea using a pulsed, reflective THz imaging system.
Starting Page	3021
Ending Page	3024
File Size	517954
Page Count	4
File Format	PDF
ISBN	9781424441235
ISSN	1557170X
DOI	10.1109/IEMBS.2010.5626146
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2010-08-31
Publisher Place	Argentina
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Cornea Imaging Surgery Materials Mixers Reflectivity Image edge detection
Content Type	Text
Resource Type	Article
Subject	Signal Processing Biomedical Engineering Health Informatics Computer Vision and Pattern Recognition

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