NDLI: Paired-pulse stimulation at glutamatergic synapses

Content Provider	IEEE Xplore Digital Library
Author	Bouteiller, J.-M.C. Allam, S.L. Greget, R. Ambert, N. Hu, E.Y. Bischoff, S. Baudry, M. Berger, T.W.
Copyright Year	2010
Description	Author affiliation: Department of Biological Sciences, University of Southern California, Hedco Neuroscience Building, Los Angeles, 90089-2520 USA (Baudry, M.) \|\| Department of Biomedical Engineering, University of Southern California, Los Angeles, 90089-1111 USA (Berger, T.W.) \|\| Rhenovia Pharma, Mulhouse, FRANCE (Ambert, N.; Bischoff, S.) \|\| Department of Biomedical Engineering, University of Southern California, Los Angeles, USA (Allam, S.L.; Hu, E.Y.) \|\| Rhenovia Pharma, 20c, rue de Chemnitz, 68100 Mulhouse, FRANCE (Greget, R.) \|\| Department of Biomedical Engineering, University of Southern California, 1042 Downey Way, DRB Building, Los Angeles, 90089-1111 USA (Bouteiller, J.-M.C.)
Abstract	Paired-pulse stimulation is a standard protocol that has been used for decades to characterize dynamic systems: the differences in responses to two sequential identical stimuli as a function of inter-stimulus interval provide quantitative information on the dynamics of the system. In neuroscience, the paired-pulse protocol is also widely used at multiple levels of analysis, from behavioral conditioning to synaptic plasticity, and in particular to define the biomolecular mechanism of learning and memory. In a system as small and complex as synapses, it is extremely challenging - if not impossible - to experimentally gain access to the multitude of possible readouts. In the present study, we first introduce a computational synaptic modeling platform that we developed and calibrated based on experimental data from both our laboratories and a variety of publications. We then show how this platform allows not only to replicate experimental data, but also to go beyond technological boundaries and investigate the main parameters responsible for regulation of synaptic transmission and plasticity. The results provide critical information regarding the respective role of various subsynaptic processes and of their interactions. Additionally, this approach can strengthen our understanding of potential dysfunctions (pathologies) and suggest potential approaches to re-establish normal function.
Starting Page	787
Ending Page	790
File Size	314815
Page Count	4
File Format	PDF
ISBN	9781424441235
ISSN	1557170X
DOI	10.1109/IEMBS.2010.5626491
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2010-08-31
Publisher Place	Argentina
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Calcium Neurotransmitters Computational modeling Protocols Biomedical engineering Mathematical model Neuroscience
Content Type	Text
Resource Type	Article
Subject	Signal Processing Biomedical Engineering Health Informatics Computer Vision and Pattern Recognition

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

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