NDLI: Antiplasmodial and cytotoxic activities of medicinal plants traditionally used in the village of Kiohima, Uganda.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Lacroix, Damien Prado, Soizic Kamoga, Dennis Kasenene, John Namukobe, Jane Krief, Sabrina Dumontet, Vincent Mouray, Elisabeth Bodo, Bernard Brunois, Florence
Spatial Coverage	Uganda
Description	Country affiliation: France Author Affiliation: Lacroix D ( Molécules de Communication et Adaptation des Micro-Organismes, FRE 3206 CNRS/MNHN, Muséum National d'Histoire Naturelle, 57 rue Cuvier, 75005 Paris, France.)
Abstract	AIM OF THE STUDY: In Uganda, malaria is the most common disease and Ugandan people largely rely on traditional medicine. In this context, we carried out an ethnobotanical study on the Kiohima village, located close to the Kibale National Park in South-Western Uganda and investigated in vitro the antiplasmodial and cytotoxic activities of selected medicinal plants. MATERIALS AND METHODS: Seventy-five plants-using adults (men and women) were interviewed to find out their plant use. From these information, 48 plants used in traditional medicine were identified and according to their reported uses and to bibliographic data, several parts of 28 plants (leaves, barks, roots), were selected and collected for biological evaluations. These samples were dried, extracted with ethyl acetate and the crude extracts were assayed for in vitro antiplasmodial and cytotoxic activities at 10 µg/mL. RESULTS: One third of the screened plants showed a significant antiplasmodial activity with inhibition greater than 50% at 10 µg/mL. CONCLUSION: These results may indicate a possible explanation of the use of some medicinal plant against malaria in the village of Kiohima and have also allowed to highlight a plant with potent antimalarial activity: Citropsis articulata root barks.
File Format	HTM / HTML
ISSN	03788741
Issue Number	2
Volume Number	133
e-ISSN	18727573
Journal	Journal of Ethnopharmacology
Language	English
Publisher	Elsevier
Publisher Date	2011-01-27
Publisher Place	Ireland
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Ethnopharmacology Antimalarials Pharmacology Antineoplastic Agents, Phytogenic Plants, Medicinal Adult Isolation & Purification Cell Line, Tumor Ethnopharmacology Female Humans Malaria, Falciparum Drug Therapy Male Medicine, African Traditional Phytotherapy Plant Extracts Chemistry Plasmodium Falciparum Drug Effects Uganda Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Drug Discovery Pharmacology

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