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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Wang, Qing-Tong Zhang, Ling-Ling Wu, Hua-Xun Wei, Wei |
| Description | Country affiliation: China Author Affiliation: Wang QT ( Institute of Clinical Pharmacology, Anhui Medical University, Key Laboratory of Anti-inflammatory and Immunopharmacology of Education Ministry, Meishan Road, Hefei 230032, Anhui Province, China.) |
| Abstract | AIM OF THE STUDY: To investigate the expression of ß-arrestins in fibroblast-like synoviocytes (FLS) from collagen-induced arthritis (CIA) rats and the effect of total glucosides of paeony (TGP). MATERIALS AND METHODS: TGP and glucosides of tripterygium wilfordii (GTW) were intragastriclly administrated to collagen-induced arthritis (CIA) rats after immunization. The secondary inflammatory reaction was evaluated by hind paw swelling, polyarthritis index and histopathological changes. Antibodies to type II collagen (CII) were determined by enzyme-linked immunosorbent assay (ELISA). Synoviocyte proliferations were determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl (MTT) assay. The expression of ß-arrestins in synoviocytes from CIA rats was measured by western blot. RESULTS: The administration of TGP (25, 50, 100 mg/kg) depressed hind paw swelling and decreased the arthritis scores of CIA rats. TGP improved the pathologic manifestations of CIA. Serum anti-CII antibodies level increased significantly in CIA rats, while TGP had no effect on it. Fibroblast-like synoviocytes (FLS) proliferation was inhibited by TGP (50, 100 mg/kg). On d14, d28 after immunization, ß-arrestins expression greatly up-regulated in synoviocytes from CIA rats and then returned to baseline levels on d42 after immunization. TGP (50, 100 mg/kg) significantly reduced the expression of ß-arrestins. CONCLUSION: An inflammatory process in vivo induces an up-regulation of ß-arrestins in synoviocytes from CIA rats while TGP can inhibit this change, which might be one of the important mechanisms for TGP to produce a marked therapeutic effect on RA. |
| File Format | HTM / HTML |
| ISSN | 03788741 |
| Issue Number | 2 |
| Volume Number | 133 |
| e-ISSN | 18727573 |
| Journal | Journal of Ethnopharmacology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2011-01-27 |
| Publisher Place | Ireland |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Ethnopharmacology Arrestins Metabolism Arthritis, Experimental Drug Therapy Drugs, Chinese Herbal Therapeutic Use Glucosides Paeonia Animals Immunology Pathology Autoantibodies Blood Chin Collagen Type Ii Ethnopharmacology Fibroblasts Drug Effects Male Chemistry Phytotherapy Plants, Medicinal Rats Rats, Sprague-dawley Synovial Membrane Up-regulation Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Drug Discovery Pharmacology |
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